Title : Histamine and tumor necrosis factor-alpha production from purified rat brain mast cells mediated by substance P.

Pub. Date : 1999 Feb 25

PMID : 10208592






3 Functional Relationships(s)
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1 A pure population of BMC challenged with 10(-8) M SP gave 78% histamine release (HR) and secreted 600 pg/ml of tumor necrosis factor-alpha (TNF-alpha) as determined by ELISA. bmc tumor necrosis factor Rattus norvegicus
2 A pure population of BMC challenged with 10(-8) M SP gave 78% histamine release (HR) and secreted 600 pg/ml of tumor necrosis factor-alpha (TNF-alpha) as determined by ELISA. bmc tumor necrosis factor Rattus norvegicus
3 The secretion of histamine and TNF-alpha from BMC after stimulation with SP supports the hypothesis that these mediators could induce an initial response in neuroinflammatory diseases. bmc tumor necrosis factor Rattus norvegicus