Title : Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy.

Pub. Date : 1999 Mar 8

PMID : 10201846






1 Functional Relationships(s)
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1 Potent, subnanomolar thrombin inhibitors 4, 5, and 6 are developed through side chain optimization of novel, benzo[b]thiophene-based small organic entities 2 and 3 and through SAR additivity studies of the new structural elements identified. Thiophenes coagulation factor II, thrombin Homo sapiens