Title : Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction.

Pub. Date : 1998 Jun

PMID : 10200500






1 Functional Relationships(s)
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1 Furthermore, nuclear import of grB proceeded through an intact nuclear membrane, as the nuclei of cells whose cytoplasm was pre-loaded with 70 kDa FITC-dextran excluded dextran for up to 90 min while still undergoing apoptosis in response to perforin and grB. fluorescein isothiocyanate dextran granzyme B Mus musculus