Title : Effects of L-NAME and 7-NI on NOS catalytic activity and behavioral outcome after traumatic brain injury in the rat.

Pub. Date : 1999 Mar

PMID : 10195468






4 Functional Relationships(s)
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1 This study investigated the effects of nitro-L-arginine-methyl ester (L-NAME) and 3-bromo-7-nitroindazole (7-NI) treatment on cNOS catalytic activity and sensorimotor behavioral outcome after TBI. 3-bromo-7-nitroindazole nitric oxide synthase 3 Rattus norvegicus
2 This study investigated the effects of nitro-L-arginine-methyl ester (L-NAME) and 3-bromo-7-nitroindazole (7-NI) treatment on cNOS catalytic activity and sensorimotor behavioral outcome after TBI. 3-bromo-7-nitroindazole nitric oxide synthase 3 Rattus norvegicus
3 Pretreatment with L-NAME and 7-NI significantly reduced injury-induced cNOS activation (47.7 +/- 42.6 %, p < 0.05, and 96.16 +/- 12.76, p < 0.05, respectively). 3-bromo-7-nitroindazole nitric oxide synthase 3 Rattus norvegicus
4 Pretreatment with L-NAME and 7-NI also inhibited cNOS activity within the contralateral noninjured cerebral cortex compared to vehicle-treated rats (L-NAME 43.7 +/- 12.47%, p < 0.05; 7-NI 36.8 +/- 7.47%, p < 0.05). 3-bromo-7-nitroindazole nitric oxide synthase 3 Rattus norvegicus