Title : Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL.

Pub. Date : 1999 Apr

PMID : 10194480






1 Functional Relationships(s)
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Protein Name
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1 Transgenic mice that overexpress the nuclear form of sterol regulatory element binding protein-1a (SREBP-1a) in liver (TgBP-1a mice) were shown previously to overproduce cholesterol and fatty acids and to accumulate massive amounts of cholesterol and triglycerides in hepatocytes. Fatty Acids sterol regulatory element binding transcription factor 1 Mus musculus