Title : Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells.

Pub. Date : 1999 Apr

PMID : 10103034






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Omeprazole, thiabendazole, carbendazim, 2-mercaptobenzimidazole and 2-mercapto-5-methoxybenzimidazole caused a dose-dependent increase in CYP1A1 protein levels that reached maximum effect at 250 microm, as measured by Western blot. Thiabendazole cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus
2 Northern blot analysis confirmed an extensive increase of CYP1A1 mRNA induced by omeprazole and 2-mercapto-5-methoxybenzimidazole which was 32% and 49% of maximal induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) respectively, whereas thiabendazole and carbendazim showed approximately 15% increase as compared to TCDD. Thiabendazole cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus