Pub. Date : 1999 Mar 5
PMID : 10100621
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of tyrosine phosphorylation of phospholipase C gamma1 in the signaling pathway of HMG-CoA reductase inhibitor-induced cell death of L6 myoblasts. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 2 | The present study was aimed to elucidate the molecular target(s) of these tyrosine phosphorylations induced by HCRI and demonstrated that simvastatin induces tyrosine phosphorylation of phospholipase C (PLC) gamma1. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 3 | The present study was aimed to elucidate the molecular target(s) of these tyrosine phosphorylations induced by HCRI and demonstrated that simvastatin induces tyrosine phosphorylation of phospholipase C (PLC) gamma1. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 4 | This tyrosine phosphorylation of PLC-gamma1 caused the increment of the intracellular inositol triphosphate (IP3) levels in L6 myoblasts. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 5 | Pretreatment of the cells with herbimycin A, a specific inhibitor of protein tyrosine kinase, inhibited a simvastatin-induced increase in IP3 level in the cells as well as tyrosine phosphorylation of PLC-gamma1. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |
| 6 | Thus, these results strongly suggest that simvastatin-induced tyrosine phosphorylation of PLC-gamma1 plays, at least in part, an important role for the development of simvastatin-induced cell death. | Tyrosine | phospholipase C gamma 1 | Homo sapiens |