Title : Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the phosphatidylinositol 3-kinase signaling pathway.

Pub. Date : 1999 Feb 26

PMID : 10094466






2 Functional Relationships(s)
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1 Gastrin-induced PI 3-kinase activity was coprecipitated with p60Src and p125FAK and was inhibited by herbimycin A, the selective Src inhibitor PP-2 or cytochalasin D, which disrupts the actin cytoskeleton and prevents p125FAK activity. Cytochalasin D SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
2 Gastrin-induced PI 3-kinase activity was coprecipitated with p60Src and p125FAK and was inhibited by herbimycin A, the selective Src inhibitor PP-2 or cytochalasin D, which disrupts the actin cytoskeleton and prevents p125FAK activity. Cytochalasin D SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens