Pub. Date : 1999 Apr
PMID : 10082587
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Integrin-induced activation of Src family PTKs, tyrosyl phosphorylation of several focal adhesion proteins, MAPK activation, and the ability to spread on fibronectin were defective in SHP-2 mutant fibroblasts but were restored upon SHP-2 expression. | cyclo(tyrosyl-tyrosyl) | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 2 | Our data suggest a positive-feedback model in which, upon integrin engagement, basal levels of c-Src activity catalyze the tyrosyl phosphorylation of SHPS-1, thereby recruiting SHP-2 to the plasma membrane, where, perhaps by further activating Src PTKs, SHP-2 transduces positive signals for downstream events such as MAPK activation and cell shape changes. | cyclo(tyrosyl-tyrosyl) | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 3 | Our data suggest a positive-feedback model in which, upon integrin engagement, basal levels of c-Src activity catalyze the tyrosyl phosphorylation of SHPS-1, thereby recruiting SHP-2 to the plasma membrane, where, perhaps by further activating Src PTKs, SHP-2 transduces positive signals for downstream events such as MAPK activation and cell shape changes. | cyclo(tyrosyl-tyrosyl) | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |