Title : Mitogen-activated protein kinase and phosphorylation of connexin43 are not sufficient for the disruption of gap junctional communication by platelet-derived growth factor and tetradecanoylphorbol acetate.

Pub. Date : 1999 Apr

PMID : 10082136






3 Functional Relationships(s)
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1 Furthermore, pretreatment with hydrogen peroxide (H2O2), a potent MAPK activator but inefficient GJC/Cx43 modulator, abrogated PDGF- or TPA-induced disruption of GJC. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens
2 While a 5 min H2O2 pretreatment abolished both PDGF- and TPA-induced Cx43 phosphorylation and GJC blockade, a simultaneous H2O2 treatment interfered only with GJC closure but not with the phosphorylation of Cx43 induced by PDGF and TPA. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens
3 While a 5 min H2O2 pretreatment abolished both PDGF- and TPA-induced Cx43 phosphorylation and GJC blockade, a simultaneous H2O2 treatment interfered only with GJC closure but not with the phosphorylation of Cx43 induced by PDGF and TPA. Tetradecanoylphorbol Acetate gap junction protein alpha 1 Homo sapiens