Pub. Date : 1999 Mar 24
PMID : 10080957
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic T cells. | Tyrosine | megakaryocyte-associated tyrosine kinase | Homo sapiens |
| 2 | The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic T cells. | Tyrosine | megakaryocyte-associated tyrosine kinase | Homo sapiens |
| 3 | Interestingly, Chk specifically bound tyrosine phosphorylated paxillin. | Tyrosine | megakaryocyte-associated tyrosine kinase | Homo sapiens |
| 4 | Using GST fusion proteins, we determined that the Chk SH2 domain, not the SH3 domain, bound tyrosine phosphorylated paxillin. | Tyrosine | megakaryocyte-associated tyrosine kinase | Homo sapiens |
| 5 | Using Far Western analysis, we revealed that the Chk SH2 domain directly associates with tyrosine phosphorylated paxillin. | Tyrosine | megakaryocyte-associated tyrosine kinase | Homo sapiens |
| 6 | These studies provide important insight into the role of Chk in tyrosine mediated signaling, as well as T cell physiology. | Tyrosine | megakaryocyte-associated tyrosine kinase | Homo sapiens |