Title : Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential.

Pub. Date : 1999 Jan

PMID : 10078840






1 Functional Relationships(s)
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1 Furafylline, sulphaphenazole, omeprazole, quinidine and ketoconazole were identified as specific markers for the respective CYP1A2 (IC50 = 6 microM), CYP2C9 (0.7 microM), CYP2C19 (6 microM), CYP2D6 (0.02 microM) and CYP3A4 (0.2 microM) inhibition screens. Ketoconazole cytochrome P450 family 2 subfamily C member 9 Homo sapiens