Title : Mechanisms of growth stimulation by suramin in non-small-cell lung cancer cell lines.

Pub. Date : 1999

PMID : 10071987






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The effect of suramin on epidermal growth factor receptor (EGFR) was determined by analyzing receptor phosphorylation and dimerization. Suramin epidermal growth factor receptor Homo sapiens
2 The effect of suramin on epidermal growth factor receptor (EGFR) was determined by analyzing receptor phosphorylation and dimerization. Suramin epidermal growth factor receptor Homo sapiens
3 PPADS had no effect on the growth stimulation by suramin; however suramin treatment resulted in rapid phosphorylation and dimerization of EGFR. Suramin epidermal growth factor receptor Homo sapiens
4 Rather, it appears that suramin acts via an interaction with EGFR, but not with purinergic receptors. Suramin epidermal growth factor receptor Homo sapiens