Title : Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase.

Pub. Date : 1999 Jan

PMID : 10071186






2 Functional Relationships(s)
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1 We have found similar S-phase arrest in both WRN and control cells after treatment with the DNA-topoisomerase-I-trapping drug camptothecin; this may be responsible for the drug-exposure-related growth inhibition seen in both cell types. Camptothecin WRN RecQ like helicase Homo sapiens
2 The mechanism of camptothecin-induced cell death in WRN-deficient LCLs appears to be through apoptosis, a phenotype that strongly differentiates WRN-deficient from wild-type LCLs. Camptothecin WRN RecQ like helicase Homo sapiens