Pub. Date : 1999 Jan
PMID : 10071186
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We have found similar S-phase arrest in both WRN and control cells after treatment with the DNA-topoisomerase-I-trapping drug camptothecin; this may be responsible for the drug-exposure-related growth inhibition seen in both cell types. | Camptothecin | WRN RecQ like helicase | Homo sapiens |
2 | The mechanism of camptothecin-induced cell death in WRN-deficient LCLs appears to be through apoptosis, a phenotype that strongly differentiates WRN-deficient from wild-type LCLs. | Camptothecin | WRN RecQ like helicase | Homo sapiens |