Title : Hprt mutant frequency and molecular analysis of Hprt mutations in Fischer 344 rats treated with thiotepa.

Pub. Date : 1999 Feb

PMID : 10069464






3 Functional Relationships(s)
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1 These results indicate that the induction of lymphocyte Hprt mutants is a sensitive biomarker for the carcinogenicity of thiotepa and that the types of mutations found in the lymphocyte Hprt gene reflect the kinds of DNA damage produced by thiotepa. Thiotepa hypoxanthine phosphoribosyltransferase 1 Rattus norvegicus
2 These results indicate that the induction of lymphocyte Hprt mutants is a sensitive biomarker for the carcinogenicity of thiotepa and that the types of mutations found in the lymphocyte Hprt gene reflect the kinds of DNA damage produced by thiotepa. Thiotepa hypoxanthine phosphoribosyltransferase 1 Rattus norvegicus
3 These results indicate that the induction of lymphocyte Hprt mutants is a sensitive biomarker for the carcinogenicity of thiotepa and that the types of mutations found in the lymphocyte Hprt gene reflect the kinds of DNA damage produced by thiotepa. Thiotepa hypoxanthine phosphoribosyltransferase 1 Rattus norvegicus