Pub. Date : 1998 Mar
PMID : 10065930
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | All of the drugs with a selective affinity at 5-HT1A receptors interacted significantly with 5-hydroxytryptophan. | 5-Hydroxytryptophan | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
2 | The suppressant effect of 5-hydroxytryptophan was antagonized or reversed by buspirone, a partial agonist at postsynaptic 5-HT1A receptors, and also by the "silent" 5-HT1A receptor antagonist WAY 100635, but not by the full agonist 8-OH-DPAT. | 5-Hydroxytryptophan | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
3 | The suppressant effect of 5-hydroxytryptophan was antagonized or reversed by buspirone, a partial agonist at postsynaptic 5-HT1A receptors, and also by the "silent" 5-HT1A receptor antagonist WAY 100635, but not by the full agonist 8-OH-DPAT. | 5-Hydroxytryptophan | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
4 | Administration of 5-hydroxytryptophan may consequently represent a valid approach to analyse further the role of 5-HT agents, in particular those acting at 5-HT1A receptors, in animal models of anxiety. | 5-Hydroxytryptophan | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |