Title : Characterization of serotonergic mechanisms involved in the behavioural inhibition induced by 5-hydroxytryptophan in a modified light-dark test in mice.

Pub. Date : 1998 Mar

PMID : 10065930






4 Functional Relationships(s)
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1 All of the drugs with a selective affinity at 5-HT1A receptors interacted significantly with 5-hydroxytryptophan. 5-Hydroxytryptophan 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
2 The suppressant effect of 5-hydroxytryptophan was antagonized or reversed by buspirone, a partial agonist at postsynaptic 5-HT1A receptors, and also by the "silent" 5-HT1A receptor antagonist WAY 100635, but not by the full agonist 8-OH-DPAT. 5-Hydroxytryptophan 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
3 The suppressant effect of 5-hydroxytryptophan was antagonized or reversed by buspirone, a partial agonist at postsynaptic 5-HT1A receptors, and also by the "silent" 5-HT1A receptor antagonist WAY 100635, but not by the full agonist 8-OH-DPAT. 5-Hydroxytryptophan 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
4 Administration of 5-hydroxytryptophan may consequently represent a valid approach to analyse further the role of 5-HT agents, in particular those acting at 5-HT1A receptors, in animal models of anxiety. 5-Hydroxytryptophan 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus