Pub. Date : 1999 Feb
PMID : 10048930
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Mutation of Asp 262, located 5.5 A distal to the active site, demonstrates it is essential for catalysis in the high-activity ERK2-dependent conformation of Pyst1 but not for the low-activity ERK2-independent form, suggesting that ERK2 induces closure of the Asp 262 loop over the active site, thereby enhancing Pyst1 catalytic efficiency. | Aspartic Acid | mitogen-activated protein kinase 1 | Homo sapiens |
2 | Mutation of Asp 262, located 5.5 A distal to the active site, demonstrates it is essential for catalysis in the high-activity ERK2-dependent conformation of Pyst1 but not for the low-activity ERK2-independent form, suggesting that ERK2 induces closure of the Asp 262 loop over the active site, thereby enhancing Pyst1 catalytic efficiency. | Aspartic Acid | mitogen-activated protein kinase 1 | Homo sapiens |