Title : Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex.

Pub. Date : 1999 Feb 25

PMID : 10047461






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cyclin E-cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex. raltitrexed cyclin dependent kinase 2 Homo sapiens
2 Tomudex treatment resulted in the decrease in p27(kip1) expression, with an increase in cyclin E and cdk2 protein expression and kinase activities 24 h after a 2-h exposure. raltitrexed cyclin dependent kinase 2 Homo sapiens