| 1 |
35173459 | Shifting the Biosynthesis of Leukotrienes Toward Specialized Pro-Resolving Mediators by the 5-Lipoxygenase-Activating Protein (FLAP) Antagonist BRP-201. | 2022 |
4 |
| 2 |
35300294 | Combined Machine Learning and GRID-Independent Molecular Descriptor (GRIND) Models to Probe the Activity Profiles of 5-Lipoxygenase Activating Protein Inhibitors. | 2022 |
1 |
| 3 |
34094977 | ALOX5AP Predicts Poor Prognosis by Enhancing M2 Macrophages Polarization and Immunosuppression in Serous Ovarian Cancer Microenvironment. | 2021 |
2 |
| 4 |
34765025 | Epigenetic regulation mechanism of DNA methylation and miRNAs on the expression of the ALOX5AP gene in patients with ischemic stroke. | 2021 Dec |
3 |
| 5 |
34805632 | Design of FLAIR: a Phase 2b Study of the 5-Lipoxygenase Activating Protein Inhibitor AZD5718 in Patients With Proteinuric CKD. | 2021 Nov |
1 |
| 6 |
34971430 | Ethoxy acetalated dextran-based nanocarriers accomplish efficient inhibition of leukotriene formation by a novel FLAP antagonist in human leukocytes and blood. | 2021 Dec 31 |
4 |
| 7 |
30291962 | A 5‑lipoxygenase-specific sequence motif impedes enzyme activity and confers dependence on a partner protein. | 2019 Apr |
1 |
| 8 |
30869888 | Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease. | 2019 May 9 |
1 |
| 9 |
30929436 | Novel Chemical Series of 5-Lipoxygenase-Activating Protein Inhibitors for Treatment of Coronary Artery Disease. | 2019 May 9 |
1 |
| 10 |
28784429 | Drug discovery approaches targeting 5-lipoxygenase-activating protein (FLAP) for inhibition of cellular leukotriene biosynthesis. | 2018 Jun 10 |
5 |
| 11 |
29597170 | Identification of multi-target inhibitors of leukotriene and prostaglandin E2 biosynthesis by structural tuning of the FLAP inhibitor BRP-7. | 2018 Apr 25 |
1 |
| 12 |
28005436 | Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents. | 2017 May |
1 |
| 13 |
28160477 | The arachidonate 5-lipoxygenase activating protein gene polymorphism is associated with the risk of scleroderma-related interstitial lung disease: a multicentre European Scleroderma Trials and Research group (EUSTAR) study. | 2017 May 1 |
4 |
| 14 |
28218273 | Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening. | 2017 Feb 20 |
1 |
| 15 |
28839250 | Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase. | 2017 Aug 24 |
2 |
| 16 |
26922224 | 4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP). | 2016 May 4 |
2 |
| 17 |
26944113 | Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index. | 2016 Mar 15 |
1 |
| 18 |
27129215 | A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors. | 2016 Jun 10 |
6 |
| 19 |
27347071 | Targeted deep resequencing of ALOX5 and ALOX5AP in patients with diabetes and association of rare variants with leukotriene pathways. | 2016 Jul |
4 |
| 20 |
27592027 | BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly. | 2016 Nov 1 |
3 |
| 21 |
29648709 | INHIBITORS OF LEUKOTRIENES SYNTHESIS: NOVEL AGENTS AND THEIR IMPLEMENTATION. | 2016 Jul |
2 |
| 22 |
26173130 | The Intracellular Localisation and Phosphorylation Profile of the Human 5-Lipoxygenase Δ13 Isoform Differs from That of Its Full Length Counterpart. | 2015 |
1 |
| 23 |
24641614 | The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP). | 2014 Jun |
1 |
| 24 |
24681156 | Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits. | 2014 Jun |
1 |
| 25 |
24905297 | An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis. | 2014 Sep |
2 |
| 26 |
25034252 | Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. | 2014 Aug 5 |
1 |
| 27 |
25211287 | Expression of leukotriene biosynthetic enzymes in tonsillar tissue of children with obstructive sleep apnea: a prospective nonrandomized study. | 2014 Oct |
1 |
| 28 |
23600432 | 5-Lipoxygenase inhibitors: a review of recent patents (2010-2012). | 2013 Jul |
1 |
| 29 |
23746795 | Association of ALOX5AP1 SG13S114T/A variant with ischemic stroke, stroke subtypes and aspirin resistance. | 2013 Aug 15 |
1 |
| 30 |
22222457 | Structure-based drug design on membrane protein targets: human integral membrane protein 5-lipoxygenase-activating protein. | 2012 |
2 |
| 31 |
22607880 | Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP). | 2012 Jun 15 |
3 |
| 32 |
22726381 | Association of ALOX5AP haplotypes with susceptibility to coronary artery disease in a Chinese Han population. | 2012 Jul |
2 |
| 33 |
23015755 | The nuclear membrane leukotriene synthetic complex is a signal integrator and transducer. | 2012 Nov |
1 |
| 34 |
23194405 | Disruption of the alox5ap gene ameliorates focal ischemic stroke: possible consequence of impaired leukotriene biosynthesis. | 2012 Nov 30 |
6 |
| 35 |
21248314 | Leukotriene inflammatory mediators meet their match. | 2011 Jan 19 |
1 |
| 36 |
22206291 | The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers. | 2011 Dec 29 |
1 |
| 37 |
20067482 | The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. | 2010 Apr |
2 |
| 38 |
20194722 | Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappaB and microRNAs 135a and 199a-5p. | 2010 Apr 1 |
1 |
| 39 |
20810156 | ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos. | 2010 Oct |
2 |
| 40 |
18775537 | Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. | 2009 Apr |
1 |
| 41 |
19130089 | Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis. | 2009 Mar |
2 |
| 42 |
19239910 | MK-886, an inhibitor of the 5-lipoxygenase-activating protein, inhibits cyclooxygenase-1 activity and suppresses platelet aggregation. | 2009 Apr 17 |
1 |
| 43 |
19456278 | Inhibitors of 5-lipoxygenase activating protein: WO 2008/030369. | 2009 Oct |
1 |
| 44 |
19876784 | FLAP inhibitors for the treatment of inflammatory diseases. | 2009 Nov |
3 |
| 45 |
18187210 | What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. | 2008 Feb |
2 |
| 46 |
18374923 | ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention. | 2008 Nov |
1 |
| 47 |
18398223 | Candidate genes of the 5-lipoxygenase pathway in acute coronary syndrome: a pilot study. | 2008 Apr |
1 |
| 48 |
17504658 | Etiology of exercise-induced asthma: physical stress-induced transcription. | 2007 Apr |
2 |
| 49 |
17600184 | Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. | 2007 Jul 27 |
4 |
| 50 |
16144515 | 5-Lipoxygenase-activating protein homodimer in human neutrophils: evidence for a role in leukotriene biosynthesis. | 2006 Jan 1 |
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