| 1 |
35105345 | Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis. | 2022 Feb 1 |
2 |
| 2 |
35108535 | Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions. | 2022 Feb 1 |
3 |
| 3 |
35130302 | Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells. | 2022 |
2 |
| 4 |
33646427 | Reprogramming of mitochondrial proline metabolism promotes liver tumorigenesis. | 2021 Dec |
2 |
| 5 |
33761308 | Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression. | 2021 Jul |
2 |
| 6 |
33771508 | Disease variants of human Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2). | 2021 May 30 |
2 |
| 7 |
33830435 | African Swine Fever Virus Protein E199L Promotes Cell Autophagy through the Interaction of PYCR2. | 2021 Apr |
1 |
| 8 |
34003320 | Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target. | 2021 Dec |
5 |
| 9 |
34107832 | Phenyl-substituted aminomethylene-bisphosphonates inhibit human P5C reductase and show antiproliferative activity against proline-hyperproducing tumour cells. | 2021 Dec |
4 |
| 10 |
34273023 | PYCR, a key enzyme in proline metabolism, functions in tumorigenesis. | 2021 Dec |
5 |
| 11 |
34291342 | Isozymes of P5C reductase (PYCR) in human diseases: focus on cancer. | 2021 Dec |
10 |
| 12 |
34390414 | Proline metabolism in cancer. | 2021 Dec |
3 |
| 13 |
34769188 | P5C as an Interface of Proline Interconvertible Amino Acids and Its Role in Regulation of Cell Survival and Apoptosis. | 2021 Oct 29 |
13 |
| 14 |
32213586 | Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis. | 2020 Apr 7 |
11 |
| 15 |
32953737 | Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome. | 2020 Aug |
2 |
| 16 |
32960509 | Proteomic patterns associated with response to breast cancer neoadjuvant treatment. | 2020 Sep |
1 |
| 17 |
33083024 | The Janus-like role of proline metabolism in cancer. | 2020 |
2 |
| 18 |
33109600 | In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1. | 2020 Dec 25 |
12 |
| 19 |
33424902 | Appropriate Activity Assays Are Crucial for the Specific Determination of Proline Dehydrogenase and Pyrroline-5-Carboxylate Reductase Activities. | 2020 |
2 |
| 20 |
30593514 | TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem-Like Cells in a Redox-Sensitive Manner. | 2019 Mar 15 |
2 |
| 21 |
30783087 | Kindlin-2 links mechano-environment to proline synthesis and tumor growth. | 2019 Feb 19 |
4 |
| 22 |
31108370 | SIRT3 regulates cancer cell proliferation through deacetylation of PYCR1 in proline metabolism. | 2019 Jul |
6 |
| 23 |
31131313 | Mechano-regulation of proline metabolism and cancer progression by kindlin-2. | 2019 |
2 |
| 24 |
31362921 | A fragment-like approach to PYCR1 inhibition. | 2019 Sep 15 |
4 |
| 25 |
29403556 | Pyrroline-5-carboxylate reductase 1 promotes proliferation and inhibits apoptosis in non-small cell lung cancer. | 2018 Jan |
3 |
| 26 |
29562167 | Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis. | 2018 Mar 20 |
3 |
| 27 |
29648801 | The Proline Cycle As a Potential Cancer Therapy Target. | 2018 Jun 26 |
15 |
| 28 |
27677826 | In silico screening, molecular docking, and molecular dynamics studies of SNP-derived human P5CR mutants. | 2017 Aug |
4 |
| 29 |
28194412 | Effect of R119G Mutation on Human P5CR1 Dynamic Property and Enzymatic Activity. | 2017 |
3 |
| 30 |
28258219 | Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1. | 2017 Apr 28 |
11 |
| 31 |
28379297 | Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers. | 2017 May 1 |
2 |
| 32 |
26878238 | Tumour-specific proline vulnerability uncovered by differential ribosome codon reading. | 2016 Feb 25 |
3 |
| 33 |
26284089 | Evolution of plant δ(1)-pyrroline-5-carboxylate reductases from phylogenetic and structural perspectives. | 2015 |
4 |
| 34 |
26320891 | Recurrent De Novo Mutations Affecting Residue Arg138 of Pyrroline-5-Carboxylate Synthase Cause a Progeroid Form of Autosomal-Dominant Cutis Laxa. | 2015 Sep 3 |
2 |
| 35 |
26598224 | Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides. | 2015 Nov 24 |
2 |
| 36 |
24431009 | Human pyrroline-5-carboxylate reductase (PYCR1) acts on Δ(1)-piperideine-6-carboxylate generating L-pipecolic acid. | 2014 May |
2 |
| 37 |
24930674 | Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production. | 2014 May 30 |
2 |
| 38 |
23041351 | The nitric oxide donor sodium nitroprusside regulates polyamine and proline metabolism in leaves of Medicago truncatula plants. | 2013 Mar |
1 |
| 39 |
23373819 | Cis-trans isomerizations of proline residues are key to bradykinin conformations. | 2013 Feb 27 |
1 |
| 40 |
23743200 | DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. | 2013 Jun 28 |
1 |
| 41 |
24035636 | Genotype-phenotype spectrum of PYCR1-related autosomal recessive cutis laxa. | 2013 Nov |
4 |
| 42 |
21744012 | Δ1-pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo. | 2012 Jun |
1 |
| 43 |
22201749 | Substrate channeling in proline metabolism. | 2012 Jan 1 |
3 |
| 44 |
22615405 | Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. | 2012 Jun 5 |
2 |
| 45 |
23024808 | Functional specialization in proline biosynthesis of melanoma. | 2012 |
3 |
| 46 |
21487760 | Defect in proline synthesis: pyrroline-5-carboxylate reductase 1 deficiency leads to a complex clinical phenotype with collagen and elastin abnormalities. | 2011 Jun |
2 |
| 47 |
19576563 | Mutation in pyrroline-5-carboxylate reductase 1 gene in families with cutis laxa type 2. | 2009 Jul |
2 |
| 48 |
17673295 | An FcgammaRIIa-binding peptide that mimics the interaction between FcgammaRIIa and IgG. | 2008 Jan |
2 |
| 49 |
18036351 | Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress. | 2008 Feb 15 |
5 |
| 50 |
18401542 | Human Delta1-pyrroline-5-carboxylate synthase: function and regulation. | 2008 Nov |
1 |