dinaciclib

cyclin dependent kinase 1 ; Homo sapiens







18 Article(s)
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1 34534577 Combined Cyclin-Dependent Kinase Inhibition Overcomes MAPK/Extracellular Signal-Regulated Kinase Kinase Inhibitor Resistance in Plexiform Neurofibroma of Neurofibromatosis Type I. 2022 Mar 1
2 35417031 Dinaciclib inhibits the stemness of two subtypes of human breast cancer cells by targeting the FoxM1 and Hedgehog signaling pathway. 2022 May 1
3 32816920 CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer. 2021 May 2
4 32375399 Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib. 2020 May 4 1
5 33125153 Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: Implications for future clinical trials in pancreatic cancer. 2020 Dec 1
6 31207099 Study of the mechanism by which dinaciclib induces apoptosis and cell cycle arrest of lymphoma Raji cells through a CDK1-involved pathway. 2019 Aug 4
7 29233910 Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer. 2018 Mar 1
8 28207834 A cyclin-dependent kinase inhibitor, dinaciclib in preclinical treatment models of thyroid cancer. 2017 1
9 27486754 Inhibition of cyclin dependent kinase 9 by dinaciclib suppresses cyclin B1 expression and tumor growth in triple negative breast cancer. 2016 Aug 30 1
10 27550941 Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2. 2016 Nov 1
11 25395429 Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma. 2015 Jan 15 2
12 25947565 A phase 1 study with dose expansion of the CDK inhibitor dinaciclib (SCH 727965) in combination with epirubicin in patients with metastatic triple negative breast cancer. 2015 Aug 1
13 25962959 Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer. 2015 Jun 20 2
14 24362465 Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism. 2014 Mar 1
15 25107301 Dinaciclib for the treatment of breast cancer. 2014 Sep 3
16 25217392 Clinical study of the novel cyclin-dependent kinase inhibitor dinaciclib in combination with rituximab in relapsed/refractory chronic lymphocytic leukemia patients. 2014 Nov 1
17 25289887 MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis. 2014 1
18 23053255 Effect of aprepitant on the pharmacokinetics of the cyclin-dependent kinase inhibitor dinaciclib in patients with advanced malignancies. 2012 Dec 1