zosuquidar trihydrochloride

ATP binding cassette subfamily B member 1 ; Homo sapiens







23 Article(s)
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1 33962209 The study of Raddeanin A cerebrovascular endothelial cell trafficking through P-glycoprotein. 2021 Jun 25 1
2 29146563 Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates. 2018 Jan 15 1
3 29673999 Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro. 2018 Aug 3
4 30108983 Live-cell fluorescence imaging: assessment of thioflavin T uptake in human epidermal carcinoma cells. 2018 Jun 1 1
5 24524365 The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier. 2014 Mar 3 1
6 22228402 Zosuquidar and an albumin-binding prodrug of zosuquidar reverse multidrug resistance in breast cancer cells of doxorubicin and an albumin-binding prodrug of doxorubicin. 2012 Jul 1
7 21148080 Endoxifen, the active metabolite of tamoxifen, is a substrate of the efflux transporter P-glycoprotein (multidrug resistance 1). 2011 Mar 1
8 17583464 Role of xenobiotic efflux transporters in resistance to vincristine. 2008 Feb 1
9 18157518 Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). 2008 Feb 2
10 17454628 Phase I/II trial of a P-glycoprotein inhibitor, Zosuquidar.3HCl trihydrochloride (LY335979), given orally in combination with the CHOP regimen in patients with non-Hodgkin's lymphoma. 2007 Apr 1
11 15809877 Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours. 2005 Aug 1
12 14718607 Contributions of CYP3A4, P-glycoprotein, and serum protein binding to the intestinal first-pass extraction of saquinavir. 2004 Mar 2
13 15161679 A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxorubicin in patients with advanced malignancy. 2004 May 15 3
14 15257929 Clinical effects and P-glycoprotein inhibition in patients with acute myeloid leukemia treated with zosuquidar trihydrochloride, daunorubicin and cytarabine. 2004 Jul 1
15 12455064 Modulation of P-glycoprotein but not MRP1- or BCRP-mediated drug resistance by LY335979. 2003 Jan 1 10
16 12712010 Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. 2003 Mar-Apr 1
17 11331075 Modulation by LY335979 of P-glycoprotein function in multidrug-resistant cell lines and human natural killer cells. 2001 Jun 1 4
18 11356921 Effect of capillary efflux transport inhibition on the determination of probe recovery during in vivo microdialysis in the brain. 2001 Jun 1
19 10783828 Diverse effects of P-glycoprotein inhibitory agents on human leukemia cells expressing the multidrug resistance protein (MRP). 2000 Apr 1
20 10820137 Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. 2000 Jun 1
21 10869171 Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. 2000 Jul 4 2
22 10374882 Growth inhibition, cytokinesis failure and apoptosis of multidrug-resistant leukemia cells after treatment with P-glycoprotein inhibitory agents. 1999 May 1
23 10411602 Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. 1999 Aug 8