Amides

coagulation factor II, thrombin ; Homo sapiens







31 Article(s)
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1 35467071 The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease. 2022 Jun 20 1
2 30558884 Accurate Prediction of Amide Exchange in the Fast Limit Reveals Thrombin Allostery. 2019 Jan 8 1
3 29634247 Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin. 2018 May 8 1
4 26468766 Thrombomodulin Binding Selects the Catalytically Active Form of Thrombin. 2015 Nov 3 1
5 21526769 Thermodynamic compensation upon binding to exosite 1 and the active site of thrombin. 2011 May 31 1
6 19448297 The fabrication, characterization and application of aptamer-functionalized Si-nanowire FET biosensors. 2009 Jun 10 1
7 16784223 Amide H/2H exchange reveals a mechanism of thrombin activation. 2006 Jun 27 1
8 17341635 Distinct activity of peptide mimetic intracellular ligands (pepducins) for proteinase-activated receptor-1 in multiple cells/tissues. 2006 Dec 1
9 15122890 Allosteric changes in solvent accessibility observed in thrombin upon active site occupation. 2004 May 11 1
10 11178915 Solvent accessibility of the thrombin-thrombomodulin interface. 2001 Feb 23 3
11 10636249 Structure-activity and crystallographic analysis of a new class of non-amide-based thrombin inhibitor. 2000 Jan 3 2
12 10632045 Thrombin receptor-activating peptides (TRAPs): investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies. 1999 Nov 2
13 9544200 Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: rapid structure-activity studies by solid-phase synthesis. 1998 Mar 26 1
14 9873397 In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors. 1998 Jul 7 1
15 9341205 New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain. 1997 Oct 28 1
16 7582980 Amide and alpha-keto carbonyl inhibitors of thrombin based on arginine and lysine: synthesis, stability and biological characterization. 1995 Aug 1
17 7582983 Peptide-derived transition state analogue inhibitors of thrombin; synthesis, activity and selectivity. 1995 Aug 1
18 7597064 An allosteric switch controls the procoagulant and anticoagulant activities of thrombin. 1995 Jun 20 1
19 7837275 Conformational transitions linked to active site ligation in human thrombin: effect on the interaction with fibrinogen and the cleavable platelet receptor. 1995 Jan 27 3
20 8373370 Effect of temperature on the association step in thrombin-fibrinogen interaction. 1993 Sep 1 1
21 8393345 Thrombin-fibrinogen interaction: pH dependence and effects of the slow-->fast transition. 1993 Jul 27 1
22 8424791 The linkage between binding of the C-terminal domain of hirudin and amidase activity in human alpha-thrombin. 1993 Jan 15 1
23 8461303 Design of a linker for trivalent thrombin inhibitors: interaction of the main chain of the linker with thrombin. 1993 Apr 6 1
24 1445891 Energetics of thrombin-fibrinogen interaction. 1992 Nov 24 1
25 1731875 Modulation of thrombin-fibrinogen interaction by specific ion effects. 1992 Jan 14 1
26 2955429 [Synthetic inhibitors of serine proteinases. 32. Inhibition of trypsin, plasmin and thrombin by amides of N-alpha-substituted 4-amidinophenylalanine. Effect of various amino acids and blocking groups of the n-alpha residue on inhibitory activity]. 1987 Feb 1
27 6336652 Wasp sting anaphylaxis. 1983 Jan 1
28 6177613 N alpha-arylsulfonyl-omega-amidinophenyl-alpha-aminoalkyl-carboxylic acid amides as specific thrombin inhibitors. 1982 1
29 6212947 [Synthetic inhibitors of serine proteinases. Part 26: Inhibition of trypsin, plasmin and thrombin by amides of N alpha-arylsulfonylated 2-amino-4-(4-amidino-phenyl) butyric acid and 2-amino-5-amidinophenyl valeric acids (author's transl)]. 1982 Apr 3
30 6458047 [Synthetic inhibitors of serine proteinases. Part 25: Inhibition of trypsin, plasmin and thrombin by amides of N alpha-substituted amidinophenylalanines and 3-amidinophenyl-3-aminopropionic acids (author's transl)]. 1981 Sep 2
31 284381 Do cleavages of amides by serine proteases occur through a stepwise pathway involving tetrahedral intermediates? 1979 Feb 1