| 1 |
34978431 | How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen. | 2022 Jan 18 |
2 |
| 2 |
35260173 | A novel insight into mechanism of derangement of coagulation balance: interactions of quantum dots with coagulation-related proteins. | 2022 Mar 8 |
1 |
| 3 |
33925363 | Proton Bridging in Catalysis by and Inhibition of Serine Proteases of the Blood Cascade System. | 2021 Apr 27 |
1 |
| 4 |
34159782 | Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin. | 2021 Nov 23 |
2 |
| 5 |
31743711 | Mechanism and inhibition kinetics of peptide P13 as thrombin inhibitor. | 2020 May 1 |
1 |
| 6 |
32450796 | Probing contacts of inhibitor locked in transition states in the catalytic triad of DENV2 type serine protease and its mutants by 1H, 19F and 15 N NMR spectroscopy. | 2020 May 25 |
2 |
| 7 |
29471734 | Probing light chain mutation effects on thrombin via molecular dynamics simulations and machine learning. | 2019 Mar |
4 |
| 8 |
30884308 | Synthesis of CC, CN coupled novel substituted dibutyl benzothiazepinone derivatives and evaluation of their thrombin inhibitory activity. | 2019 Jun |
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| 9 |
31086923 | Fluorine-substituted quinoidal thiophene with a F-H hydrogen bond locked conformation for high-performance n-channel organic transistors. | 2019 May 28 |
1 |
| 10 |
29382582 | Structure-function studies of prothrombin Amrita, a dysfunctional prothrombin characterized by point mutation at Arg553 → Gln. | 2018 Apr 15 |
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| 11 |
29406112 | Inhibition of thrombin by functionalized C60 nanoparticles revealed via in vitro assays and in silico studies. | 2018 Jan |
1 |
| 12 |
29634247 | Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin. | 2018 May 8 |
1 |
| 13 |
29973622 | Direct evidence of a low barrier hydrogen bond in the catalytic triad of a Serine protease. | 2018 Jul 4 |
1 |
| 14 |
27816890 | Modulating hydrogen-bond basicity within the context of protein-ligand binding: A case study with thrombin inhibitors that reveals a dominating role for desolvation. | 2017 Jan 5 |
1 |
| 15 |
28371253 | Charges Shift Protonation: Neutron Diffraction Reveals that Aniline and 2-Aminopyridine Become Protonated Upon Binding to Trypsin. | 2017 Apr 18 |
1 |
| 16 |
27248478 | Elucidation of Nonadditive Effects in Protein-Ligand Binding Energies: Thrombin as a Case Study. | 2016 Jun 23 |
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| 17 |
27507430 | Large-scale molecular dynamics simulation: Effect of polarization on thrombin-ligand binding energy. | 2016 Aug 10 |
2 |
| 18 |
27771530 | Thrombin and protein C pathway in peripheral nerve Schwann cells. | 2016 Dec 17 |
1 |
| 19 |
27777004 | Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles. | 2016 Nov 15 |
1 |
| 20 |
27874042 | Electrical Stimulus Controlled Binding/Unbinding of Human Thrombin-Aptamer Complex. | 2016 Nov 22 |
1 |
| 21 |
26634958 | Dewetting of S1-Pocket via Water Channel upon Thrombin-Substrate Association Reaction. | 2015 Dec 31 |
3 |
| 22 |
23517305 | Proton bridging in the interactions of thrombin with hirudin and its mimics. | 2013 Apr 9 |
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| 23 |
21635208 | Exploring QSARs for inhibitory effect of a set of heterocyclic thrombin inhibitors by multilinear regression refined by artificial neural network and molecular docking simulations. | 2012 Apr |
1 |
| 24 |
23152789 | On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different. | 2012 |
1 |
| 25 |
21736375 | Interaction of thrombin with sucrose octasulfate. | 2011 Aug 16 |
1 |
| 26 |
21970497 | Interaction between resveratrol and thrombin and its biological implication. | 2011 Dec |
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| 27 |
20148533 | Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors. | 2010 Mar 11 |
2 |
| 28 |
20156458 | Non-additivity of functional group contributions in protein-ligand binding: a comprehensive study by crystallography and isothermal titration calorimetry. | 2010 Apr 9 |
2 |
| 29 |
17950494 | Structure of a novel thrombin inhibitor with an uncharged D-amino acid as P1 residue. | 2008 Jun |
4 |
| 30 |
16411898 | Probing the importance of hydrogen bonds in the active site of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation. | 2006 May 1 |
1 |
| 31 |
17034250 | Dielectric studies of water clusters in cyclodextrins: Relevance to the transition between slow and fast forms of thrombin. | 2006 Oct 19 |
1 |
| 32 |
15617822 | NMR study of the folding-unfolding mechanism for the thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG). | 2005 Feb 1 |
1 |
| 33 |
15731882 | Noncovalent inhibition of the serine proteases, alpha-chymotrypsin and trypsin by trifluoro(organo)borates. | 2005 Mar 7 |
1 |
| 34 |
15771442 | In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. | 2005 Mar 24 |
3 |
| 35 |
15122890 | Allosteric changes in solvent accessibility observed in thrombin upon active site occupation. | 2004 May 11 |
1 |
| 36 |
12742021 | Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors. | 2003 May 23 |
1 |
| 37 |
12021429 | Epitope mapping of a monoclonal antibody against human thrombin by H/D-exchange mass spectrometry reveals selection of a diverse sequence in a highly conserved protein. | 2002 Jun |
1 |
| 38 |
11178915 | Solvent accessibility of the thrombin-thrombomodulin interface. | 2001 Feb 23 |
1 |
| 39 |
11292354 | A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site. | 2001 Apr 13 |
5 |
| 40 |
11495587 | Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa. | 2001 Aug 16 |
1 |
| 41 |
10987367 | New bivalent thrombin inhibitors with N(alpha)(methyl)arginine at the P1-position. | 2000 Jul |
1 |
| 42 |
10987422 | Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor. | 2000 Sep 4 |
1 |
| 43 |
10048334 | Breaking the low barrier hydrogen bond in a serine protease. | 1999 Feb |
1 |
| 44 |
10189177 | Small, noncovalent serine protease inhibitors. | 1999 Mar |
1 |
| 45 |
10632045 | Thrombin receptor-activating peptides (TRAPs): investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies. | 1999 Nov |
1 |
| 46 |
10927404 | Anhydrous ammonioguanidinium(2+) and dihydrated bis | 1999 Aug 1 |
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| 47 |
9108691 | The molecular environment of the Na+ binding site of thrombin. | 1997 Jan 31 |
2 |
| 48 |
9341205 | New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain. | 1997 Oct 28 |
1 |
| 49 |
8939759 | Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design. | 1996 Nov 15 |
1 |
| 50 |
7574675 | Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution. | 1995 Sep 10 |
1 |