| 1 |
34923393 | Structural insights into the activation of blood coagulation factor XI zymogen by thrombin: A computational molecular dynamics study. | 2022 Feb |
2 |
| 2 |
33471524 | How a Fragment Draws Attention to Selectivity Discriminating Features between the Related Proteases Trypsin and Thrombin. | 2021 Feb 11 |
1 |
| 3 |
34661075 | Inhibition of Arginine Methylation Impairs Platelet Function. | 2021 Oct 8 |
1 |
| 4 |
32011145 | Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins? | 2020 Mar 26 |
4 |
| 5 |
30279891 | Familial pulmonary thromboembolism with a prothrombin mutation and antithrombin resistance. | 2018 Jun |
1 |
| 6 |
28640323 | Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential. | 2017 Jul 26 |
2 |
| 7 |
28683085 | An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII. | 2017 |
1 |
| 8 |
26763231 | How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin. | 2016 Mar 18 |
2 |
| 9 |
26957205 | Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling. | 2016 May |
2 |
| 10 |
27561318 | Occupancy of human EPCR by protein C induces β-arrestin-2 biased PAR1 signaling by both APC and thrombin. | 2016 Oct 6 |
1 |
| 11 |
27681598 | Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism. | 2016 Nov 25 |
1 |
| 12 |
24094605 | Ambivalent roles of carboxypeptidase B in the lytic susceptibility of fibrin. | 2014 Jan |
1 |
| 13 |
24333681 | A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides. | 2014 Feb |
1 |
| 14 |
24354792 | Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease. | 2014 Mar |
1 |
| 15 |
25152637 | Update on argatroban for the prophylaxis and treatment of heparin-induced thrombocytopenia type II. | 2014 |
1 |
| 16 |
23265743 | Molecular defect of 'Prothrombin Amrita': substitution of arginine by glutamine (Arg553 to Gln) near the Na(+) binding loop of prothrombin. | 2013 Mar |
2 |
| 17 |
23517305 | Proton bridging in the interactions of thrombin with hirudin and its mimics. | 2013 Apr 9 |
3 |
| 18 |
23659383 | Modification of interdomain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity. | 2013 Jun 4 |
1 |
| 19 |
23775088 | Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation. | 2013 Aug 2 |
6 |
| 20 |
23940050 | Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavage. | 2013 Sep 27 |
2 |
| 21 |
24178300 | Histone H4 promotes prothrombin autoactivation. | 2013 Dec 13 |
1 |
| 22 |
22079445 | Liporetro-D-peptides - a novel class of highly selective thrombin inhibitors. | 2012 Apr |
1 |
| 23 |
22455313 | P3-P3' residues flanking scissile bonds in factor VIII modulate rates of substrate cleavage and procofactor activation by thrombin. | 2012 Apr 24 |
10 |
| 24 |
22474388 | NSP4, an elastase-related protease in human neutrophils with arginine specificity. | 2012 Apr 17 |
1 |
| 25 |
20226548 | Argatroban for elective percutaneous coronary intervention: the ARG-E04 multi-center study. | 2011 Apr 14 |
1 |
| 26 |
21719463 | Elucidation of the contribution of active site and exosite interactions to affinity and specificity of peptidylic serine protease inhibitors using non-natural arginine analogs. | 2011 Oct |
1 |
| 27 |
21893043 | Identification of the site of binding of sulfated, low molecular weight lignins on thrombin. | 2011 Sep 23 |
2 |
| 28 |
19283444 | A new non-natural arginine-like amino acid derivative with a sulfamoyl group in the side-chain. | 2010 Mar |
1 |
| 29 |
19484400 | Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity. | 2010 Apr |
1 |
| 30 |
19858193 | Regulated cleavage of prothrombin by prothrombinase: repositioning a cleavage site reveals the unique kinetic behavior of the action of prothrombinase on its compound substrate. | 2010 Jan 1 |
2 |
| 31 |
20062922 | Characterisation of an antibody specific for coagulation factor VIII that enhances factor VIII activity. | 2010 Jan |
2 |
| 32 |
20071328 | Osteopontin is cleaved at multiple sites close to its integrin-binding motifs in milk and is a novel substrate for plasmin and cathepsin D. | 2010 Mar 12 |
1 |
| 33 |
20484050 | Inhibition of thrombin formation by active site mutated (S360A) activated protein C. | 2010 Jul 23 |
4 |
| 34 |
20551327 | Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKCdelta. | 2010 Aug 20 |
1 |
| 35 |
19074424 | The roles of selected arginine and lysine residues of TAFI (Pro-CPU) in its activation to TAFIa by the thrombin-thrombomodulin complex. | 2009 Mar 13 |
1 |
| 36 |
19240027 | Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII. | 2009 Apr 24 |
8 |
| 37 |
19581306 | Regulatory mechanism of matrix metalloprotease-2 enzymatic activity by factor Xa and thrombin. | 2009 Aug 28 |
3 |
| 38 |
19689280 | Structure-activity relationships of low molecular weight heparins expose to the risk of achieving inappropriate targets in patients with renal failure. | 2009 |
2 |
| 39 |
19790060 | Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis. | 2009 Oct |
1 |
| 40 |
18081893 | Identification of a thrombin-interactive site within the FVIII A2 domain that is responsible for the cleavage at Arg372. | 2008 Feb |
3 |
| 41 |
18327399 | The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase. | 2008 Mar |
2 |
| 42 |
18392324 | Cleavage of factor XIII by human neutrophil elastase results in a novel active truncated form of factor XIII A subunit. | 2008 Apr |
1 |
| 43 |
18424440 | Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V. | 2008 Jun 13 |
2 |
| 44 |
18457426 | Factor Va alters the conformation of the Na+-binding loop of factor Xa in the prothrombinase complex. | 2008 Jun 3 |
1 |
| 45 |
18585267 | Tryptophan-contained peptide-functional nanomaterials as general spectrofluorometric reagents for enzyme. | 2008 Jun 30 |
6 |
| 46 |
18765660 | Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase. | 2008 Oct 31 |
1 |
| 47 |
17010480 | Synthesis and evaluation of a small library of graftable thrombin inhibitors derived from (L)-arginine. | 2007 Jan |
1 |
| 48 |
17287625 | Influence of coagulation factors on extrinsic thrombin generation. | 2007 Mar |
1 |
| 49 |
17456623 | Inhibition of thrombin in plasma by heparin or arginine. | 2007 Apr |
4 |
| 50 |
17636263 | Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery. | 2007 Sep 14 |
1 |