Proline

coagulation factor II, thrombin ; Homo sapiens







38 Article(s)
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Pub. Year
#Total Relationships
1 35053615 CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma. 2022 Jan 17 1
2 30468644 Fibroblast activation protein in liver fibrosis. 2019 Jan 1 1
3 30419598 Proline 36 of the Factor XIII Activation Peptide Plays a Crucial Role in Substrate Recognition and Zymogen Activation. 2018 Dec 1
4 24412428 A novel electrochemiluminescence aptasensor based on in situ generated proline and matrix polyamidoamine dendrimers as coreactants for signal amplication. 2014 May 15 1
5 24470260 Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy. 2014 Jun 1
6 25140306 The nonglycemic actions of dipeptidyl peptidase-4 inhibitors. 2014 1
7 19371038 Compounds binding to the S2-S3 pockets of thrombin. 2009 May 14 1
8 17284929 Lys, pro and trp are critical core amino acid residues recognized by FUM20, a monoclonal antibody against serine protease pan-fungal allergens. 2007 2
9 17384076 Quantum and molecular dynamics study for binding of macrocyclic inhibitors to human alpha-thrombin. 2007 Jun 15 1
10 15826939 The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases. 2005 Jun 10 1
11 16176095 [The construction and characterization of human pro-urokinase mutant]. 2005 Jul 2
12 12646027 Synthesis of novel thrombin inhibitors. Use of ring-closing metathesis reactions for synthesis of P2 cyclopentene- and cyclohexenedicarboxylic acid derivatives. 2003 Mar 27 1
13 12873514 Design and synthesis of potent and selective macrocyclic thrombin inhibitors. 2003 Aug 18 1
14 13678420 Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage. 2003 Dec 15 2
15 14654359 Directed evolution towards protease-resistant hirudin variants. 2003 Dec 3
16 14750503 A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX. 2003 Dec 1
17 10794688 New proline mimetics: synthesis of thrombin inhibitors incorporating cyclopentane- and cyclopentenedicarboxylic acid templates in the P2 position. Binding conformation investigated by X-ray crystallography. 2000 May 4 1
18 10051558 Unexpected crucial role of residue 225 in serine proteases. 1999 Mar 2 1
19 10836047 7-Azabicycloheptane carboxylic acid: a proline replacement in a boroarginine thrombin inhibitor. 1999 Dec 16 3
20 9716158 Characteristics of the interaction between thrombin exosite 1 and the sequence 269-287 [correction of 269-297] of platelet glycoprotein Ibalpha. 1998 Aug 1
21 9790668 Allosteric effects of a monoclonal antibody against thrombin exosite II. 1998 Oct 27 3
22 9850596 Effects of thrombin on the growth, protein synthesis, attachment, clustering and alkaline phosphatase activity of cultured human periodontal ligament fibroblasts. 1998 Oct 1
23 9364988 Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor. 1997 Oct 1
24 8784202 Role of the P2 residue in determining the specificity of serpins. 1996 Sep 3 1
25 8910365 p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2. 1996 Nov 1 2
26 8944419 Synthesis and study on a novel inhibitor of thrombin containing no side chain at the P1 position of the polypeptide chain. 1996 1
27 7499191 Thrombin induces activation of p38 MAP kinase in human platelets. 1995 Nov 17 2
28 7537275 Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase. 1995 May 1
29 7548057 Intermolecular interactions between protein C inhibitor and coagulation proteases. 1995 Oct 10 1
30 7563081 Thrombin-bound structures of designed analogs of human fibrinopeptide A determined by quantitative transferred NOE spectroscopy: a new structural basis for thrombin specificity. 1995 Oct 6 1
31 7744836 Development of a novel recombinant serpin with potential antithrombotic properties. 1995 May 19 2
32 1290488 Thrombin-specific inhibition by and slow cleavage of hirulog-1. 1992 May 1 1
33 1304349 The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. 1992 Apr 1
34 1547237 Conformational stability of a thrombin-binding peptide derived from the hirudin C-terminus. 1992 Mar 10 1
35 2974999 [Synthesis of N-alpha-(arylsulfonyl)-4-amidino-phenylalanyl-prolines and N-alpha-(arylsulfonylglycyl)-4-amidino-phenylalanyl-prolines and testing of them as inhibitors of serine proteinases. 33. Synthetic inhibitors of serine proteinases]. 1988 Jun 1
36 3755044 Isolation and characterization of a partial cDNA clone for heparin cofactor II1. 1986 May 29 1
37 6860783 Thrombin, a stimulator of bone resorption. 1983 Mar 1
38 6776531 Active site amino acid sequence of human factor D. 1980 Aug 1