| 1 |
34896181 | Mice lacking 5-lipoxygenase display motor deficits associated with cortical and hippocampal synapse abnormalities. | 2022 Feb |
4 |
| 2 |
33484341 | Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1. | 2021 Jan 23 |
1 |
| 3 |
33679410 | Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis. | 2021 |
1 |
| 4 |
33721755 | Blocking 5-LO pathway alleviates renal fibrosis by inhibiting the epithelial-mesenchymal transition. | 2021 Jun |
3 |
| 5 |
34677413 | Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5-/- Mice. | 2021 Oct 12 |
2 |
| 6 |
31642348 | Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme. | 2020 Jan 1 |
1 |
| 7 |
30649890 | Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease. | 2019 Apr 1 |
2 |
| 8 |
31167124 | 5-Lipoxagenase deficiency attenuates L-NAME-induced hypertension and vascular remodeling. | 2019 Sep 1 |
2 |
| 9 |
31300449 | Leukotriene Synthesis Is Critical for Medulloblastoma Progression. | 2019 Nov 1 |
1 |
| 10 |
29311656 | Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. | 2018 Feb |
1 |
| 11 |
29607621 | Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice. | 2018 Jun |
1 |
| 12 |
30122897 | Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice. | 2018 |
1 |
| 13 |
28623130 | Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34+CD38- stem and progenitor cells in chronic myeloid leukemia. | 2017 Aug 19 |
2 |
| 14 |
28737505 | Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males. | 2017 Aug 1 |
2 |
| 15 |
28894350 | Short-Term Regulation of FcγR-Mediated Phagocytosis by TLRs in Macrophages: Participation of 5-Lipoxygenase Products. | 2017 |
2 |
| 16 |
26663781 | Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. | 2016 Jan 15 |
1 |
| 17 |
26690703 | Placenta growth factor augments airway hyperresponsiveness via leukotrienes and IL-13. | 2016 Feb |
1 |
| 18 |
27198524 | Impact of Arachidonic Acid and the Leukotriene Signaling Pathway on Vasculogenesis of Mouse Embryonic Stem Cells. | 2016 |
4 |
| 19 |
27262746 | 5-lipoxygenase pathway is essential for the control of granuloma extension induced by Schistosoma mansoni eggs in lung. | 2016 Aug |
1 |
| 20 |
27530926 | Inhibition of 5-lipoxygenase suppresses vascular endothelial growth factor-induced angiogenesis in endothelial cells. | 2016 Sep 23 |
2 |
| 21 |
25583526 | 5-Lipoxygenase negatively regulates Th1 response during Brucella abortus infection in mice. | 2015 Mar |
1 |
| 22 |
25747113 | Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. | 2015 |
1 |
| 23 |
26265153 | The 5-lipoxygenase (5-LOX) Inhibitor Zileuton Reduces Inflammation and Infarct Size with Improvement in Neurological Outcome Following Cerebral Ischemia. | 2015 |
2 |
| 24 |
26432605 | 5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression. | 2015 Nov 1 |
1 |
| 25 |
26649828 | Neutrophils support lung colonization of metastasis-initiating breast cancer cells. | 2015 Dec 17 |
2 |
| 26 |
23947598 | Pivotal role of the 5-lipoxygenase pathway in lung injury after experimental sepsis. | 2014 Jan |
2 |
| 27 |
24795811 | Fracture healing and lipid mediators. | 2014 |
1 |
| 28 |
24892983 | In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis. | 2014 Sep |
2 |
| 29 |
25025775 | 5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation. | 2014 |
2 |
| 30 |
25032067 | Eicosanoids and Keratinocytes in Wound Healing. | 2014 Jul 1 |
1 |
| 31 |
25324573 | 5-Lipoxygenase pathway in experimental abdominal aortic aneurysms. | 2014 Dec |
1 |
| 32 |
23246375 | Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants. | 2013 Feb 1 |
2 |
| 33 |
23357209 | The involvement of 5-lipoxygenase activating protein in anxiety-like behavior. | 2013 May |
2 |
| 34 |
23800665 | Protection of dopaminergic neurons by 5-lipoxygenase inhibitor. | 2013 Oct |
2 |
| 35 |
23812248 | 5-Lipoxygenase facilitates healing after myocardial infarction. | 2013 Jul |
2 |
| 36 |
23859654 | Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation. | 2013 Dec |
1 |
| 37 |
23954958 | [Benzoxazole derivative B-98 ameliorates dextran sulfate sodium-induced acute murine colitis and the change of T cell profiles in acute murine colitis model]. | 2013 Jul |
1 |
| 38 |
23991239 | The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. | 2013 |
2 |
| 39 |
24288682 | 5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality. | 2013 |
2 |
| 40 |
21755457 | Selective inhibition of leukotriene receptor BLT-2 reduces vascular oxidative stress and improves endothelial function in ApoE-/- mice. | 2012 Jan |
1 |
| 41 |
22128029 | A high-fat diet induces bone loss in mice lacking the Alox5 gene. | 2012 Jan |
1 |
| 42 |
22688342 | Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice. | 2012 Sep |
1 |
| 43 |
23109727 | 5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1. | 2012 Dec 1 |
1 |
| 44 |
21270404 | 5-Lipoxygenase-deficient mice infected with Borrelia burgdorferi develop persistent arthritis. | 2011 Mar 1 |
1 |
| 45 |
21506958 | 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. | 2011 Sep |
2 |
| 46 |
19834040 | Increased synthesis of leukotrienes in the mouse model of diabetic retinopathy. | 2010 Mar |
1 |
| 47 |
19965960 | The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells. | 2010 Apr 1 |
2 |
| 48 |
20173212 | Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy. | 2010 Jul |
2 |
| 49 |
20381637 | 5-lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection. | 2010 Aug |
1 |
| 50 |
20851170 | 5-Lipoxygenase in mouse cerebellar Purkinje cells. | 2010 Dec 1 |
1 |