| 1 |
33397269 | Synergistic Interactions between GW8510 and Gemcitabine in an In Vitro Model of Pancreatic Cancer. | 2021 Oct 28 |
1 |
| 2 |
34575569 | M1 Macrophage-Derived Exosomes Loaded with Gemcitabine and Deferasirox against Chemoresistant Pancreatic Cancer. | 2021 Sep 17 |
2 |
| 3 |
31619462 | Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition. | 2020 Feb |
1 |
| 4 |
32014934 | Messenger-RNA Expression of Five Gemcitabine Sensitivity-related Genes Predicting Outcome in Advanced-stage Non-small Cell Lung Cancer. | 2020 Feb |
1 |
| 5 |
30777929 | MiR-20a-5p regulates gemcitabine chemosensitivity by targeting RRM2 in pancreatic cancer cells and serves as a predictor for gemcitabine-based chemotherapy. | 2019 May 31 |
9 |
| 6 |
30816541 | Reconstruction and analysis of circRNA‑miRNA‑mRNA network in the pathology of cervical cancer. | 2019 Apr |
1 |
| 7 |
30941318 | Genetic features associated with 18F-FDG uptake in intrahepatic cholangiocarcinoma. | 2019 Apr |
1 |
| 8 |
30999154 | Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer. | 2019 Jul |
1 |
| 9 |
29853661 | Gemcitabine resistance mediated by ribonucleotide reductase M2 in lung squamous cell carcinoma is reversed by GW8510 through autophagy induction. | 2018 Jul 16 |
6 |
| 10 |
28196013 | Prognostic Implications of Expression Profiling for Gemcitabine-Related Genes (hENT1, dCK, RRM1, RRM2) in Patients With Resectable Pancreatic Adenocarcinoma Receiving Adjuvant Chemotherapy. | 2017 May/Jun |
1 |
| 11 |
28327155 | Vasohibin 2 reduces chemosensitivity to gemcitabine in pancreatic cancer cells via Jun proto-oncogene dependent transactivation of ribonucleotide reductase regulatory subunit M2. | 2017 Mar 21 |
1 |
| 12 |
28797284 | Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2). | 2017 Aug 10 |
4 |
| 13 |
29100320 | Suppression of pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer to gemcitabine and 5FU, and inhibits the formation of pancreatic cancer stem like cells. | 2017 Sep 29 |
2 |
| 14 |
27725909 | Cell cycle dependent RRM2 may serve as proliferation marker and pharmaceutical target in adrenocortical cancer. | 2016 |
3 |
| 15 |
27748721 | Precision Medicine and Pancreatic Cancer: A Gemcitabine Pathway Approach. | 2016 Nov |
2 |
| 16 |
25738429 | Ribonucleotide reductase M2 is a promising molecular target for the treatment of oral squamous cell carcinoma. | 2015 May |
2 |
| 17 |
24879635 | Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells. | 2014 Oct |
3 |
| 18 |
24940696 | miR-211 modulates gemcitabine activity through downregulation of ribonucleotide reductase and inhibits the invasive behavior of pancreatic cancer cells. | 2014 |
2 |
| 19 |
25236447 | Using Drosophila melanogaster to identify chemotherapy toxicity genes. | 2014 Sep |
1 |
| 20 |
25499121 | Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer. | 2014 Dec 12 |
5 |
| 21 |
23335963 | Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein. | 2013 |
6 |
| 22 |
23466567 | Small interfering RNA (siRNA)-mediated silencing of the M2 subunit of ribonucleotide reductase: a novel therapeutic strategy in ovarian cancer. | 2013 May |
1 |
| 23 |
22425885 | Synthesis and in vitro evaluation of novel lipophilic monophosphorylated gemcitabine derivatives and their nanoparticles. | 2012 Jun 15 |
2 |
| 24 |
22670179 | Ribonucleotide reductase M2 does not predict survival in patients with resectable pancreatic adenocarcinoma. | 2012 |
3 |
| 25 |
21529991 | Synergistic cytotoxicity, inhibition of signal transduction pathways and pharmacogenetics of sorafenib and gemcitabine in human NSCLC cell lines. | 2011 Nov |
1 |
| 26 |
21844567 | HDM-2 inhibition suppresses expression of ribonucleotide reductase subunit M2, and synergistically enhances gemcitabine-induced cytotoxicity in mantle cell lymphoma. | 2011 Oct 13 |
1 |
| 27 |
20811706 | Ribonucleotide reductase subunit M1 assessed by quantitative double-fluorescence immunohistochemistry predicts the efficacy of gemcitabine in biliary tract carcinoma. | 2010 Oct |
3 |
| 28 |
20927319 | Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy. | 2010 Oct |
1 |
| 29 |
21166702 | Ribonucleotide reductase M2 subunit is a novel diagnostic marker and a potential therapeutic target in bladder cancer. | 2010 Dec |
2 |
| 30 |
19568409 | Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies. | 2009 Jul |
4 |
| 31 |
18414411 | Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine. | 2008 May 20 |
4 |
| 32 |
18751396 | Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer. | 2008 Jul-Aug |
1 |
| 33 |
19002265 | Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients. | 2008 |
2 |
| 34 |
17224927 | Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. | 2007 Feb 12 |
2 |
| 35 |
17530364 | Ribonucleotide reductase subunit M2 mRNA expression in pretreatment biopsies obtained from unresectable pancreatic carcinomas. | 2007 May |
3 |
| 36 |
14661056 | RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. | 2004 Feb 26 |
3 |
| 37 |
15041467 | Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone. | 2004 Apr 15 |
2 |
| 38 |
15300189 | Retrovirally mediated RNA interference targeting the M2 subunit of ribonucleotide reductase: A novel therapeutic strategy in pancreatic cancer. | 2004 Aug |
1 |
| 39 |
11489836 | Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit. | 2001 Aug |
2 |
| 40 |
11978967 | Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanism of drug resistance. | 2001 |
2 |