Folic Acid

dihydrofolate reductase ; Cricetulus griseus







2 Article(s)
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1 12416030 Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells. 2002 Sep-Oct 1
2 8440739 Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine. 1993 Feb 25 1