| 1 |
35572589 | Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness. | 2022 |
2 |
| 2 |
32032565 | MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression. | 2020 May |
2 |
| 3 |
30735559 | The organization of leukotriene biosynthesis on the nuclear envelope revealed by single molecule localization microscopy and computational analyses. | 2019 |
2 |
| 4 |
31351395 | Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors. | 2019 Oct 15 |
2 |
| 5 |
29936999 | Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue. | 2018 Sep |
3 |
| 6 |
27058978 | Investigations on the role of leukotrienes in remote hind limb preconditioning-induced cardioprotection in rats. | 2016 May 1 |
2 |
| 7 |
25907417 | The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats. | 2015 Apr 18 |
2 |
| 8 |
24747451 | Mesenteric lymph diversion abrogates 5-lipoxygenase activation in the kidney following trauma and hemorrhagic shock. | 2014 May |
1 |
| 9 |
23648742 | Effect of allergen sensitization on external root resorption. | 2013 Jul |
1 |
| 10 |
22986158 | Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury. | 2012 Dec |
1 |
| 11 |
21380805 | Anti-allergic activity of sesquiterpenes from the rhizomes of Cyperus rotundus. | 2011 Feb |
1 |
| 12 |
21442678 | Inhibition of experimental atopic dermatitis by rhubarb (rhizomes of Rheum tanguticum) and 5-lipoxygenase inhibition of its major constituent, emodin. | 2011 May |
2 |
| 13 |
20460770 | Effects of menadione, a reactive oxygen generator, on leukotriene secretion from RBL-2H3 cells. | 2010 |
1 |
| 14 |
18951527 | Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells. | 2009 Mar |
2 |
| 15 |
19277963 | 5-lipoxygenase-inhibitory constituents from Schizandra fructus and Magnolia flos. | 2009 Oct |
2 |
| 16 |
19579006 | Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo. | 2009 Aug |
1 |
| 17 |
19749079 | Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation. | 2009 Dec |
2 |
| 18 |
19884011 | Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1. | 2009 Dec 1 |
1 |
| 19 |
19884440 | Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing. | 2009 Nov |
1 |
| 20 |
18222672 | Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders. | 2008 Jun |
2 |
| 21 |
18474265 | Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages. | 2008 Jun-Jul |
1 |
| 22 |
17464212 | Leukotriene synthesis in response to A23187 is inhibited by methyl- beta-cyclodextrin in RBL-2H3 cells. | 2007 Feb 28 |
4 |
| 23 |
17711426 | Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. | 2007 Nov |
1 |
| 24 |
16442488 | Application of the ferrous oxidation-xylenol orange assay for the screening of 5-lipoxygenase inhibitors. | 2006 Apr 1 |
1 |
| 25 |
16606359 | Activation of 5-lipoxygenase after oxygen-glucose deprivation is partly mediated via NMDA receptor in rat cortical neurons. | 2006 May |
2 |
| 26 |
16689995 | Inhibition of NF-kappaB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia. | 2006 May 11 |
2 |
| 27 |
16923329 | Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats. | 2006 Sep |
1 |
| 28 |
16445567 | Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. | 2005 Dec |
1 |
| 29 |
14726295 | Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats. | 2004 May |
1 |
| 30 |
15021971 | Leukotrienes mediate 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint via CysLT-type receptors. | 2004 Feb |
1 |
| 31 |
15339030 | Effect of 5-lipoxygenase inhibition on events associated with inflammatory bowel disease in rats. | 2004 Jul |
2 |
| 32 |
12649539 | Inhibition of 5-lipoxygenase activating protein decreases proteinuria in diabetic rats. | 2003 Jan-Feb |
1 |
| 33 |
14733414 | Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis. | 2003 Sep-Oct |
1 |
| 34 |
12127993 | Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent. | 2002 Jul 26 |
1 |
| 35 |
11374881 | Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death. | 2001 Jun 1 |
1 |
| 36 |
10966751 | Symmetrical bis(heteroarylmethoxyphenyl)alkylcarboxylic acids as inhibitors of leukotriene biosynthesis. | 2000 Aug 24 |
1 |
| 37 |
10982774 | Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. | 2000 Sep |
1 |
| 38 |
11016533 | Inflammatory 5-LOX mRNA and protein are increased in brain of aging rats. | 2000 Sep-Oct |
2 |
| 39 |
10428066 | Glucocorticoids stimulate inflammatory 5-lipoxygenase gene expression and protein translocation in the brain. | 1999 Aug |
2 |
| 40 |
10668425 | Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression. | 1999 |
2 |
| 41 |
9445378 | Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. | 1998 Feb 1 |
2 |
| 42 |
9535216 | Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability. | 1998 Apr |
1 |
| 43 |
9784515 | 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. | 1998 Nov |
1 |
| 44 |
9864011 | Alveolar lining fluid regulates mononuclear phagocyte 5-lipoxygenase metabolism. | 1998 Nov |
1 |
| 45 |
12671301 | Early upregulation of hippocampal 5-lipoxygenase following systemic administration of kainate to rats. | 1998 Jun |
1 |
| 46 |
9090473 | Enhanced production of LTB4 and free radicals in rat lung by exhaustive physical exercise. | 1997 Mar |
1 |
| 47 |
9223651 | Effects of tepoxalin, a dual inhibitor of cyclooxygenase/5-lipoxygenase, on events associated with NSAID-induced gastrointestinal inflammation. | 1997 Jun |
1 |
| 48 |
8522947 | Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling. | 1996 Jan |
2 |
| 49 |
8688675 | Inhibition of leukotriene synthesis by honokiol in rat basophilic leukemia cells. | 1996 Jul |
1 |
| 50 |
8796377 | The effect of a selective 5-lipoxygenase inhibitor, zileuton, on tissue damage in acute colonic inflammation in rats. | 1996 Jun |
1 |