| 1 |
33519941 | Integrating Network Pharmacology and Experimental Models to Investigate the Mechanism of Huanglian Jiedu Decoction on Inflammatory Injury Induced by Cerebral Ischemia. | 2021 |
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32971106 | Acetyl-11-keto-β-boswellic acid prevents testicular torsion/detorsion injury in rats by modulating 5-LOX/LTB4 and p38-MAPK/JNK/Bax/Caspase-3 pathways. | 2020 Nov 1 |
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29551652 | Edaravone, a free radical scavenger, protects neuronal cells' mitochondria from ischemia by inactivating another new critical factor of the 5-lipoxygenase pathway affecting the arachidonic acid metabolism. | 2018 Jul 1 |
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| 4 |
29936999 | Trauma and hemorrhagic shock activate molecular association of 5-lipoxygenase and 5-lipoxygenase-Activating protein in lung tissue. | 2018 Sep |
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| 5 |
25907417 | The protective effect of caffeic acid on global cerebral ischemia-reperfusion injury in rats. | 2015 Apr 18 |
2 |
| 6 |
26491436 | 17β Estradiol Modulates Perfusion Pressure and Expression of 5-LOX and CYP450 4A in the Isolated Kidney of Metabolic Syndrome Female Rats. | 2015 |
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| 7 |
26495739 | [ROLE OF THROMBOXANE AND LEUKOTRIENES IN MECHANISMS OF CONTRACTILE REACTIONS OF PORTAL VEIN, INDUCED BY ACETYLCHLINE AND PHENYLEPHRINE]. | 2015 |
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| 8 |
23172924 | Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats. | 2013 Jan |
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| 9 |
24465039 | The effects of zileuton and montelukast in reperfusion-induced arrhythmias in anesthetized rats. | 2013 Dec |
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| 10 |
22986158 | Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury. | 2012 Dec |
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| 11 |
20460770 | Effects of menadione, a reactive oxygen generator, on leukotriene secretion from RBL-2H3 cells. | 2010 |
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| 12 |
18951527 | Oxygen-glucose deprivation activates 5-lipoxygenase mediated by oxidative stress through the p38 mitogen-activated protein kinase pathway in PC12 cells. | 2009 Mar |
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| 13 |
19749079 | Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation. | 2009 Dec |
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| 14 |
19884440 | Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing. | 2009 Nov |
1 |
| 15 |
20011686 | Cardioprotective effect of 5-lipoxygenase gene (ALOX5) silencing in ischemia-reperfusion. | 2009 |
1 |
| 16 |
18474265 | Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages. | 2008 Jun-Jul |
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| 17 |
19066064 | [Effect of herba schizonepetae volatile oil (STO) on activity of 5-lipoxygenase in rat thoracic cavity leukocytes]. | 2008 Sep |
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| 18 |
17711426 | Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. | 2007 Nov |
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| 19 |
16606359 | Activation of 5-lipoxygenase after oxygen-glucose deprivation is partly mediated via NMDA receptor in rat cortical neurons. | 2006 May |
2 |
| 20 |
15789618 | 5-lipoxygenase expression and activity in aorta from streptozotocin-induced diabetic rats. | 2005 Jan |
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| 21 |
14676186 | Stabilization of leukotriene A4 by epithelial fatty acid-binding protein in the rat basophilic leukemia cell. | 2004 Feb 27 |
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| 22 |
15020073 | Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line. | 2004 Apr |
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| 23 |
15070903 | Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway. | 2004 Jun 11 |
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| 24 |
15475461 | Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis. | 2004 Oct 1 |
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| 25 |
12649539 | Inhibition of 5-lipoxygenase activating protein decreases proteinuria in diabetic rats. | 2003 Jan-Feb |
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| 26 |
12729844 | Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii. | 2003 May 2 |
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| 27 |
14733414 | Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis. | 2003 Sep-Oct |
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| 28 |
12127993 | Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca2+-dependent. | 2002 Jul 26 |
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| 29 |
11334860 | 5-Lipoxygenase is required for proliferation of immature cerebellar granule neurons in vitro. | 2001 Apr 20 |
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| 30 |
11374881 | Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death. | 2001 Jun 1 |
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| 31 |
11451962 | Co-localization of leukotriene a4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils. | 2001 Sep 14 |
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| 32 |
11016533 | Inflammatory 5-LOX mRNA and protein are increased in brain of aging rats. | 2000 Sep-Oct |
2 |
| 33 |
11113602 | 5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus:early response to glutamate receptor activation by kainate. | 2000 Dec |
2 |
| 34 |
10668425 | Primary cultures of rat cerebellar granule cells as a model to study neuronal 5-lipoxygenase and FLAP gene expression. | 1999 |
2 |
| 35 |
9442035 | Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase. | 1998 Jan 23 |
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| 36 |
9684751 | Mono (S) hydroxy fatty acids: novel ligands for cytosolic actin. | 1998 Jul |
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| 37 |
9748714 | Amino derivatives of phenyl alkyl thiophene as inhibitors of bone resorption. Structure-activity relationship. | 1998 Aug |
4 |
| 38 |
9784515 | 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. | 1998 Nov |
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| 39 |
12671301 | Early upregulation of hippocampal 5-lipoxygenase following systemic administration of kainate to rats. | 1998 Jun |
1 |
| 40 |
9068990 | The involvement of KCa, KATP and KV channels in vasorelaxing responses to acetylcholine in rat aortic rings. | 1997 Mar |
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| 41 |
9090473 | Enhanced production of LTB4 and free radicals in rat lung by exhaustive physical exercise. | 1997 Mar |
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| 42 |
9197987 | Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models. | 1997 May |
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| 43 |
8522947 | Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling. | 1996 Jan |
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| 44 |
8813619 | Effect of a 5-lipoxygenase inhibitor on nerve growth factor-induced thermal hyperalgesia in the rat. | 1996 Jun 13 |
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| 45 |
8816855 | Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. | 1996 Sep 6 |
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| 46 |
7603462 | Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid. | 1995 Jun |
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| 47 |
7786891 | Characterization of specific subcellular 15-hydroxyeicosatetraenoic acid (15-HETE) binding sites on rat basophilic leukemia cells. | 1995 Jun 6 |
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| 48 |
7847183 | Inhibitory activity of a series of coumarins on leukocyte eicosanoid generation. | 1994 Aug |
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| 49 |
7855310 | Reduced 5-lipoxygenase metabolism of arachidonic acid in macrophages rrom 1,25-dihydroxyvitamin D3-deficient rats. | 1994 Nov |
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| 50 |
7932529 | Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives. | 1994 Sep 16 |
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