7-ethyl-10-hydroxycamptothecin glucuronide

UDP glucuronosyltransferase family 1 member A1 ; Homo sapiens







12 Article(s)
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1 33619631 Effect of UGT1A1, CYP3A and CES Activities on the Pharmacokinetics of Irinotecan and its Metabolites in Patients with UGT1A1 Gene Polymorphisms. 2021 Mar 3
2 29932028 Pharmacokinetic and Pharmacogenetic Markers of Irinotecan Toxicity. 2019 1
3 25689738 Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of irinotecan and its main metabolites in human plasma and its application in a clinical pharmacokinetic study. 2015 2
4 22740978 Correlation between plasma concentration ratios of SN-38 glucuronide and SN-38 and neutropenia induction in patients with colorectal cancer and wild-type UGT1A1 gene. 2012 Mar 1
5 21297369 [Pharmacogenomic research for avoiding adverse reactions by anti-cancer drugs]. 2011 Feb 1
6 21840303 Hepatocyte growth factor suppresses the anticancer effect of irinotecan by decreasing the level of active metabolite in HepG2 cells. 2011 Dec 1 2
7 17700594 Influence of UGT1A9 intronic I399C>T polymorphism on SN-38 glucuronidation in Asian cancer patients. 2008 Jun 1
8 17713471 Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma. 2008 Apr 1
9 18281753 [CPT-11 (Irinotecan)]. 2008 Feb 1
10 16965601 Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer. 2006 Nov 1
11 12485959 Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D. 2003 Jan 1
12 11259359 Pharmacogenetics of anticancer agents: lessons from amonafide and irinotecan. 2001 Apr 1