3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol

insulin receptor ; Homo sapiens







14 Article(s)
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1 34964902 Dual IGF1R/IR inhibitors in combination with GD2-CAR T-cells display a potent anti-tumor activity in diffuse midline glioma H3K27M-mutant. 2021 Dec 29 1
2 31490549 IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer. 2020 Apr 15 1
3 32373071 Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical Carcinoma. 2020 1
4 31480400 Ceritinib-Induced Regression of an Insulin-Like Growth Factor-Driven Neuroepithelial Brain Tumor. 2019 Aug 30 1
5 29731738 Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Influences Sensitivity to Anti-IGF System Agents Through the Translational Regulation of IGF1R. 2018 1
6 28760855 Dual Targeting of Insulin Receptor and KIT in Imatinib-Resistant Gastrointestinal Stromal Tumors. 2017 Sep 15 3
7 26561558 InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma. 2016 Apr 1 1
8 26831715 Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors. 2016 Jun 15 1
9 27200287 Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR. 2016 1
10 25212606 A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors. 2015 Feb 15 2
11 25795408 Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study. 2015 Apr 1
12 22932796 Targeting the insulin-like growth factor-1 receptor to overcome bortezomib resistance in preclinical models of multiple myeloma. 2012 Oct 18 1
13 20924128 Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer. 2010 Oct 1
14 21425998 Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor. 2009 Sep 1