Doxorubicin

MYC proto-oncogene, bHLH transcription factor ; Homo sapiens







56 Article(s)
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1 35414060 Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage. 2022 Apr 12 1
2 33524223 Doxorubicin-induced senescence promotes stemness and tumorigenicity in EpCAM-/CD133- nonstem cell population in hepatocellular carcinoma cell line, HuH-7. 2021 Aug 1
3 33544209 Honokiol antagonizes doxorubicin resistance in human breast cancer via miR-188-5p/FBXW7/c-Myc pathway. 2021 May 2
4 34732441 Clinicopathologic and Prognostic Significance of Bruton's Tyrosine Kinase Expression in Diffuse Large B-Cell Lymphoma. 2021 Nov 1
5 32096603 Integrated bioinformatics analysis of the crucial candidate genes and pathways associated with glucocorticoid resistance in acute lymphoblastic leukemia. 2020 Apr 1
6 32106373 MiR-451a attenuates doxorubicin resistance in lung cancer via suppressing epithelialmesenchymal transition (EMT) through targeting c-Myc. 2020 May 4
7 33256379 Treatment of patients with MYC rearrangement positive large B-cell lymphoma with R-CHOP plus lenalidomide: results of a multicenter HOVON phase II trial. 2020 Dec 1 3
8 30834613 Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in chemosensitization. 2019 Jul 1
9 30914792 Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma. 2019 Oct 1
10 31132617 Liposome-coated nano doxorubicin induces apoptosis on oral squamous cell carcinoma CAL-27 cells. 2019 Jul 2
11 29185119 PRMT5 determines the sensitivity to chemotherapeutics by governing stemness in breast cancer. 2018 Apr 1
12 29750424 Stat3/Oct-4/c-Myc signal circuit for regulating stemness-mediated doxorubicin resistance of triple-negative breast cancer cells and inhibitory effects of WP1066. 2018 Jul 3
13 30020405 PIM1 overexpression in T-cell lymphomas protects tumor cells from apoptosis and confers doxorubicin resistance by upregulating c-myc expression. 2018 Aug 1 1
14 30501868 Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study. 2018 Dec 1
15 28232072 BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility. 2017 Apr 1
16 28291124 MYC Protein-positive Diffuse Large B-Cell Lymphoma Features an Activated B-Cell Receptor Signal Pathway. 2017 Apr 1
17 28819559 Growth inhibitory efficacy of natural products in a model for triple negative molecular subtype of clinical breast cancer. 2017 Sep 1
18 28843484 Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug. 2017 Sep 27 1
19 26596829 Differential effects of c-myc and ABCB1 silencing on reversing drug resistance in HepG2/Dox cells. 2016 May 3
20 26922833 Nemorubicin and doxorubicin bind the G-quadruplex sequences of the human telomeres and of the c-MYC promoter element Pu22. 2016 Jun 1
21 26927665 Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma. 2016 Jul 15 1
22 27231235 Farnesiferol c induces apoptosis via regulation of L11 and c-Myc with combinational potential with anticancer drugs in non-small-cell lung cancers. 2016 May 27 1
23 25468432 Molecular classification of MYC-driven B-cell lymphomas by targeted gene expression profiling of fixed biopsy specimens. 2015 Jan 1
24 25835050 c-Myc modulation: a key role in melanoma drug response. 2015 1
25 25871400 Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation. 2015 Apr 30 1
26 25894737 Establishment of a porcine pancreatic stem cell line using T-REx(™) system-inducible Wnt3a expression. 2015 Jun 1
27 26218671 Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling. 2015 Nov 1 1
28 26528706 Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis. 2015 Nov 3 3
29 24719189 MYC protein expression is associated with poor prognosis in diffuse large B cell lymphoma patients treated with RCHOP chemotherapy. 2014 Jul 1
30 24840054 Involvement of HIF-1α activation in the doxorubicin resistance of human osteosarcoma cells. 2014 Jul 1
31 23335369 MYC status in concert with BCL2 and BCL6 expression predicts outcome in diffuse large B-cell lymphoma. 2013 Mar 21 1
32 23555992 Prognostic and predictive significance of MYC and KRAS alterations in breast cancer from women treated with neoadjuvant chemotherapy. 2013 1
33 25073258 An unusual case of mycosis fungoides with high proliferation index and C-MYC/8q24 translocation. 2013 Nov-Dec 1
34 22128783 Synthesis of rocaglamide hydroxamates and related compounds as eukaryotic translation inhibitors: synthetic and biological studies. 2012 Jan 12 1
35 22213394 Prognostic significance of MYC, BCL2, and BCL6 rearrangements in patients with diffuse large B-cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab. 2012 Sep 1 1
36 22851565 Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. 2012 Oct 1 1
37 21575199 IκB kinases increase Myc protein stability and enhance progression of breast cancer cells. 2011 May 16 1
38 22132187 Identification of cytotoxic drugs that selectively target tumor cells with MYC overexpression. 2011 1
39 20460382 Multifunctional nanoparticles delivering small interfering RNA and doxorubicin overcome drug resistance in cancer. 2010 Jul 16 1
40 20498406 Rearrangement of MYC is associated with poor prognosis in patients with diffuse large B-cell lymphoma treated in the era of rituximab. 2010 Jul 10 1
41 18166243 Increase of therapeutic effects by treating melanoma with targeted combinations of c-myc antisense and doxorubicin. 2008 Feb 18 2
42 16316634 Enhancing the antiproliferative effect of topoisomerase II inhibitors using a polypeptide inhibitor of c-Myc. 2006 Jan 12 3
43 16788862 Downregulation of the PI3K/Akt survival pathway in cells with deregulated expression of c-Myc. 2006 Aug 1
44 14990581 Loss of MYC confers resistance to doxorubicin-induced apoptosis by preventing the activation of multiple serine protease- and caspase-mediated pathways. 2004 May 14 4
45 15153331 Glutathione depletion induced by c-Myc downregulation triggers apoptosis on treatment with alkylating agents. 2004 May-Jun 1
46 12736715 Effect of apoptogenic stimuli on colon carcinoma cell lines with a different c-myc expression level. 2003 Jun 1
47 12390804 [Up-regulation of c-myc expression in MCF-7/Adr human breast cancer cells and its association with resistance against doxorubicin]. 2002 Feb 4
48 12435808 c-Myc exerts a protective function through ornithine decarboxylase against cellular insults. 2002 Dec 1
49 11585056 Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells. 2001 Sep 1 1
50 9625435 Transcriptional down-regulation of c-myc expression in an erythroleukemic cell line, K562, and its doxorubicin-resistant variant by two topoisomerase II inhibitors, doxorubicin and amsacrine. 1998 Mar 2