Ethacrynic Acid

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glutathione S-transferase kappa 1 ; Homo sapiens







42 Article(s)
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1 29637702 Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug. 2018 Jun 20 4
2 29666895 Suppression of glutathione S-transferases potentiates the cytotoxic effect of phenethyl isothiocyanate in cholangiocarcinoma cells. 2018 Jun 3
3 29698741 Prevention of 4-hydroxynonenal-induced lipolytic activation by carnosic acid is related to the induction of glutathione S-transferase in 3T3-L1 adipocytes. 2018 Jun 3
4 30136368 Identification of a co-target for enhancing efficacy of sorafenib in HCC through a quantitative modeling approach. 2018 Nov 2
5 28834763 Overcoming resistance to cisplatin by inhibition of glutathione S-transferases (GSTs) with ethacraplatin micelles in vitro and in vivo. 2017 Nov 2
6 27475235 Assembly of ligands interaction models for glutathione-S-transferases from Plasmodium falciparum, human and mouse using enzyme kinetics and molecular docking. 2016 Oct 1
7 28347082 Preparation of GST Inhibitor Nanoparticle Drug Delivery System and Its Reversal Effect on the Multidrug Resistance in Oral Carcinoma. 2015 Sep 29 2
8 22633414 Inhibitor mediated protein degradation. 2012 May 25 1
9 21278620 Association of GSTM1 null polymorphism with isosorbide-5-mononitrate cardiovascular response and involvement of CGRP in healthy Chinese male volunteers. 2011 Mar 1
10 22025407 Evaluation of platinum-ethacrynic acid conjugates in the treatment of mesothelioma. 2011 Dec 9 4
11 17340122 Hepatocytes isolated from preneoplastic rat livers are resistant to ethacrynic acid cytotoxicity. 2007 Aug 2
12 17918761 Organometallic ruthenium inhibitors of glutathione-S-transferase P1-1 as anticancer drugs. 2007 Dec 2
13 14998680 Cellular glutathione prevents cytolethality of monomethylarsonic acid. 2004 Mar 1 4
14 12781783 Exploration of in vitro pro-drug activation and futile cycling by glutathione S-transferases: thiol ester hydrolysis and inhibitor maturation. 2003 Jun 15 1
15 11259628 Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms. 2001 Apr 2
16 11412109 3-Methyleneoxindole: an affinity label of glutathione S-transferase pi which targets tryptophan 38. 2001 Jun 26 1
17 10814804 Activities of affinity-isolated glutathione S-transferase (GST) from channel catfish whole intestine. 2000 May 1 1
18 10211938 Rapid development of glutathione-S-transferase-dependent drug resistance in vitro and its prevention by ethacrynic acid. 1999 Feb 8 1
19 9890665 Inhibition of apoptosis is the cause of resistance to doxorubicin in human breast adenocarcinoma cells. 1998 1
20 9406235 Importance of glutathione and associated enzymes in drug response. 1997 4
21 8548883 Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines. 1996 1
22 8567338 Ethacrynic acid: a novel radiation enhancer in human carcinoma cells. 1996 Jan 15 2
23 7476889 Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors. 1995 Oct 2
24 7488239 Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells. 1995 Oct 12 7
25 7786310 Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells. 1995 May 26 2
26 7927920 DT-diaphorase as a determinant of sensitivity to adriamycin in non-small-cell lung-cancer cell lines. 1994 Oct 15 2
27 8020149 Protection by transfected glutathione S-transferase isozymes against carcinogen-induced alkylation of cellular macromolecules in human MCF-7 cells. 1994 Jun 2
28 8280615 Reversing of chlorambucil resistance by ethacrynic acid in a B-CLL patient. 1993 Oct 1
29 8284946 Ethacrynic acid and its glutathione conjugate as inhibitors of glutathione S-transferases. 1993 Aug 7
30 8329448 Interactions of glutathione S-transferase-pi with ethacrynic acid and its glutathione conjugate. 1993 Jul 10 8
31 8442764 Isoenzyme selective irreversible inhibition of rat and human glutathione S-transferases by ethacrynic acid and two brominated derivatives. 1993 Feb 9 3
32 1316774 A study of ethacrynic acid as a potential modifier of melphalan and cisplatin sensitivity in human lung cancer parental and drug-resistant cell lines. 1992 May 1
33 1412509 Inhibition of human hepatic glutathione S-transferase isozymes by ethacrynic acid and its metabolites. 1992 Sep 8
34 1449522 Glutathione S-transferase-dependent conjugation of leukotriene A4-methyl ester to leukotriene C4-methyl ester in mammalian skin. 1992 Nov 17 1
35 1505071 Nitrogen mustard-DNA interaction in melphalan-resistant mammary carcinoma cells with elevated intracellular glutathione and glutathione-S-transferase activity. 1992 2
36 1540159 Tyrosine-7 is an essential residue for the catalytic activity of human class PI glutathione S-transferase: chemical modification and site-directed mutagenesis studies. 1992 Feb 14 1
37 1731759 Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid. 1992 Jan 1 7
38 1717140 Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin. 1991 Oct 1 2
39 1783605 Purification and characterization of acidic form of glutathione S-transferase in human fetal livers: high similarity to placental form. 1991 Nov 2
40 2130591 [Subcellular distribution of glutathione S-transferase in Chinese fetal liver]. 1990 Sep 3
41 2222516 Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate. 1990 Oct 1 1
42 3390866 Selective inhibition of leukotriene C4 synthesis and natural killer activity by ethacrynic acid. 1988 Jul 1