dacomitinib

epidermal growth factor receptor ; Homo sapiens







132 Article(s)
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1 34074804 Chronicles of EGFR Tyrosine Kinase Inhibitors: Targeting EGFR C797S Containing Triple Mutations. 2022 Jan 1 1
2 35007861 Potential applications of clickable probes in EGFR activity visualization and prediction of EGFR-TKI therapy response for NSCLC patients. 2022 Feb 15 2
3 35081479 Discovery of novel potent covalent inhibitor-based EGFR degrader with excellent in vivo efficacy. 2022 Mar 1
4 35105467 [Drug-drug interactions of tyrosine kinase inhibitors in treatment of non-small-cell lung carcinoma]. 2022 Mar 1
5 35195881 The Effect of Hepatic Impairment on the Pharmacokinetics of Dacomitinib. 2022 Mar 2
6 35305596 Rationale and design of a phase II trial of dacomitinib in advanced non-small cell lung cancer patients with uncommon epidermal growth factor receptor mutations: a prospective and single arm study (DANCE study). 2022 Mar 19 2
7 35343086 Bevacizumab plus dacomitinib combination therapy for L858R-mutated metastatic lung adenocarcinoma: A report of two cases. 2022 May 1
8 35415873 Clinical efficacy of dacomitinib in rechallenge setting for patients with epidermal growth factor receptor mutant non-small cell lung cancer: A multicenter retrospective analysis (TOPGAN2020-02). 2022 May 5
9 35462930 Acquired Concurrent EGFR T790M and Driver Gene Resistance From EGFR-TKIs Hampered Osimertinib Efficacy in Advanced Lung Adenocarcinoma: Case Reports. 2022 1
10 35626421 Utility of Next-Generation Sequencing in the Reconstruction of Clonal Architecture in a Patient with an EGFR Mutated Advanced Non-Small Cell Lung Cancer: A Case Report. 2022 May 19 3
11 32959703 Indirect analysis of first-line therapy for advanced non-small-cell lung cancer with activating mutations in a Japanese population. 2021 Jan 1
12 33112047 Remarkable response to dacomitinib in a patient with leptomeningeal carcinomatosis due to EGFR-mutant non-small cell lung cancer. 2021 Jan 9
13 33153414 EGFR tyrosine kinase inhibitors in non-small cell lung cancer: treatment paradigm, current evidence, and challenges. 2021 Oct 1
14 33251343 Dacomitinib and gedatolisib in combination with fractionated radiation in head and neck cancer. 2021 Jan 1
15 33331989 Updated Overall Survival in a Randomized Study Comparing Dacomitinib with Gefitinib as First-Line Treatment in Patients with Advanced Non-Small-Cell Lung Cancer and EGFR-Activating Mutations. 2021 Feb 1
16 33333327 Recent Advances on the Role of EGFR Tyrosine Kinase Inhibitors in the Management of NSCLC With Uncommon, Non Exon 20 Insertions, EGFR Mutations. 2021 May 2
17 33352385 Dacomitinib induces objective responses in metastatic brain lesions of patients with EGFR-mutant non-small-cell lung cancer: A brief report. 2021 Feb 6
18 33635095 Dacomitinib in first-line treatment of advanced EGFR-mutated non-small-cell lung cancer: a cost-effectiveness analysis. 2021 Mar 1
19 33651475 Dacomitinib as a retreatment for advanced non-small cell lung cancer patient with an uncommon EGFR mutation. 2021 Apr 4
20 33721611 Safety and efficacy of first-line dacomitinib in Asian patients with EGFR mutation-positive non-small cell lung cancer: Results from a randomized, open-label, phase 3 trial (ARCHER 1050). 2021 Apr 1
21 33754924 The cost-effectiveness of dacomitinib in first-line treatment of advanced/metastatic epidermal growth factor receptor mutation-positive non-small-cell lung cancer (EGFRm NSCLC) in Sweden. 2021 Jan-Dec 1
22 33937055 Case Report: Dacomitinib May Not Benefit Patients Who Develop Rare Compound Mutations After Later-Line Osimertinib Treatment. 2021 1
23 33941614 Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors. 2021 Jul 15 1
24 34093040 Cost-Effectiveness Analysis of Dacomitinib versus Gefitinib in the First-Line Treatment of EGFR-Positive Advanced or Metastatic Non-Small Cell Lung Cancer. 2021 2
25 34113397 Dacomitinib improves chemosensitivity of cisplatin-resistant human ovarian cancer cells. 2021 Jul 3
26 34120312 Evaluation of the Effect of Proton Pump Inhibitors on the Efficacy of Dacomitinib and Gefitinib in Patients with Advanced Non-Small Cell Lung Cancer and EGFR-Activating Mutations. 2021 Dec 3
27 34140482 Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer. 2021 Jun 17 1
28 34250398 Pilot Study of Dacomitinib for Patients With Metastatic EGFR-Mutant Lung Cancers With Disease Progression After Initial Treatment With Osimertinib. 2021 1
29 34268373 Cost-effectiveness analysis of dacomitinib versus gefitinib for the first-line therapy of patients with EGFR mutation-positive non-small-cell lung cancer in the United States and China. 2021 May 4
30 34397694 Successful treatment of 2 patients with brain metastases from non-small cell lung cancer with epidermal growth factor receptor mutation receiving dacomitinib: A case report. 2021 Jul 30 2
31 34564058 Simultaneous determination of dacomitinib and its major metabolite, O-desmethyl dacomitinib in human plasma by LC-MS/MS and its application to clinical testing in patients with non-small cell lung cancer. 2021 Oct 1 1
32 34602008 Cost-effectiveness analysis of the first-line EGFR-TKIs in patients with advanced EGFR-mutated non-small-cell lung cancer. 2021 Oct 11 1
33 34751504 Efficacy of dacomitinib in patients with EGFR-mutated NSCLC and brain metastases. 2021 Dec 7
34 34799322 REPORT- Clinical outcomes of using second - versus first-Generation EGFR-tkis for the First-Line treatment of advanced NSCLC patients with EGFR mutations: A meta-analysis. 2021 Jul 1
35 34926262 Case Report: Dacomitinib Overcomes Osimertinib Resistance in NSCLC Patient Harboring L718Q Mutation: A Case Report. 2021 2
36 34944068 EGFR-D770>GY and Other Rare EGFR Exon 20 Insertion Mutations with a G770 Equivalence Are Sensitive to Dacomitinib or Afatinib and Responsive to EGFR Exon 20 Insertion Mutant-Active Inhibitors in Preclinical Models and Clinical Scenarios. 2021 Dec 17 4
37 34970476 Modelled Economic Analysis for Dacomitinib-A Cost Effectiveness Analysis in Treating Patients With EGFR-Mutation-Positive Non-Small Cell Lung Cancer in China. 2021 3
38 31858327 Evaluation of the potential effect of dacomitinib, an EGFR tyrosine kinase inhibitor, on ECG parameters in patients with advanced non-small cell lung cancer. 2020 Jun 3
39 31953310 ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non-Small Cell Lung Cancer. 2020 May 1 2
40 32159882 Safety and efficacy of first-line dacomitinib in Japanese patients with advanced non-small cell lung cancer. 2020 May 1
41 32272733 Pharmacokinetic Models to Characterize the Absorption Phase and the Influence of a Proton Pump Inhibitor on the Overall Exposure of Dacomitinib. 2020 Apr 7 3
42 32292093 Is there a role for dacomitinib, a second-generation irreversible inhibitor of the epidermal-growth factor receptor tyrosine kinase, in advanced non-small cell lung cancer? 2020 Aug 4
43 32296006 Dramatic Response of Brain Metastasis from EGFR-mutation-positive NSCLC to Dacomitinib. 2020 Jul 15 4
44 32869649 Network meta analysis of first-line therapy for advanced EGFR mutation positive non-small-cell lung cancer: updated overall survival. 2020 Dec 1
45 32923886 Exploring Predictors of Response to Dacomitinib in EGFR-Amplified Recurrent Glioblastoma. 2020 2
46 30500458 Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers. 2019 Jan 1
47 30612075 Quantitative bioanalytical assay for the human epidermal growth factor receptor (HER) inhibitor dacomitinib in rat plasma by UPLC-MS/MS. 2019 Mar 20 2
48 30644426 Genetically distinct glioma stem-like cell xenografts established from paired glioblastoma samples harvested before and after molecularly targeted therapy. 2019 Jan 15 2
49 30839234 Management of common adverse events related to first-line dacomitinib use in EGFR mutation-positive non-small-cell lung cancer: a pooled safety analysis. 2019 May 1
50 30863108 First-line tyrosine kinase inhibitors in EGFR mutation-positive non-small-cell lung cancer: a network meta-analysis. 2019 3