Gefitinib

epidermal growth factor receptor ; Homo sapiens







2974 Article(s)
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1 33904654 Survival analysis for older patients with epidermal growth factor receptor mutation-positive advanced non-small cell lung cancer after progression of first-line gefitinib. 2022 Feb 3
2 34074804 Chronicles of EGFR Tyrosine Kinase Inhibitors: Targeting EGFR C797S Containing Triple Mutations. 2022 Jan 1 1
3 34348357 What management for epidermal growth factor receptor-mutated non-small-cell lung cancer, with squamous cell transformation and T790M-acquired resistance mechanisms? A Case report and review of literature. 2022 Jan 1 1
4 34352998 miR-4487 Enhances Gefitinib-Mediated Ubiquitination and Autophagic Degradation of EGFR in Non-Small Cell Lung Cancer Cells by Targeting USP37. 2022 Apr 7
5 34633106 A novel cyclic NP1 reveals obstruction of EGFR kinase activity and attenuation of EGFR-driven cell lines. 2022 Feb 2
6 34648945 Lung Cancer Driven by BRAFG469V Mutation Is Targetable by EGFR Kinase Inhibitors. 2022 Feb 1
7 34707044 Rhabdomyolysis Caused by Gefitinib Overdose. 2022 May 15 1
8 34726958 Randomized Phase III Study of Gefitinib Versus Cisplatin Plus Vinorelbine for Patients With Resected Stage II-IIIA Non-Small-Cell Lung Cancer With EGFR Mutation (IMPACT). 2022 Jan 20 2
9 34738874 AZD3759 enhances radiation effects in non-small-cell lung cancer by a synergistic blockade of epidermal growth factor receptor and Janus kinase-1. 2022 Jan 2
10 34861243 Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways. 2022 Jan 1
11 34919024 Circ_0014235 confers Gefitinib resistance and malignant behaviors in non-small cell lung cancer resistant to Gefitinib by governing the miR-146b-5p/YAP/PD-L1 pathway. 2022 Jan 2
12 34953624 Gefitinib plus tremelimumab combination in refractory non-small cell lung cancer patients harbouring EGFR mutations: The GEFTREM phase I trial. 2022 Apr 1
13 34987800 Role of the EGFR-KDD mutation as a possible mechanism of acquired resistance of non-small cell lung cancer to EGFR tyrosine kinase inhibitors: A case report. 2022 Feb 1
14 34994998 Curcumin suppresses cell proliferation and triggers apoptosis in vemurafenib-resistant melanoma cells by downregulating the EGFR signaling pathway. 2022 Apr 1
15 34996416 A novel circ_MACF1/miR-942-5p/TGFBR2 axis regulates the functional behaviors and drug sensitivity in gefitinib-resistant non-small cell lung cancer cells. 2022 Jan 7 2
16 34998839 Molecular pathways and role of epigenetics in the idiopathic pulmonary fibrosis. 2022 Feb 15 1
17 35014626 Predictive value of TCR Vβ-Jβ profile for adjuvant gefitinib in EGFR mutant NSCLC from ADJUVANT-CTONG 1104 trial. 2022 Jan 11 2
18 35046665 Efficacy and Safety of Gefitinib Plus Pemetrexed/Platinum in Advanced EGFR-Mutated Lung Adenocarcinoma Patients: A Real-World Observational Study. 2022 2
19 35068940 Effect of Gefitinib Combined with Chemotherapy in Patients with Advanced NSCLC: A Retrospective Cohort Study. 2022 2
20 35078385 Black phosphorus nanoparticles for dual therapy of non-small cell lung cancer. 2022 Jul 1
21 35105467 [Drug-drug interactions of tyrosine kinase inhibitors in treatment of non-small-cell lung carcinoma]. 2022 Mar 1
22 35122447 Effects of the epidermal growth factor receptor inhibitor, gefitinib, on lipid and hyaluronic acid synthesis in cultured HaCaT keratinocytes. 2022 Jun 1
23 35158954 Fluorescence Imaging of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer. 2022 Jan 28 1
24 35185556 Blimp-1 Upregulation by Multiple Ligands via EGFR Transactivation Inhibits Cell Migration in Keratinocytes and Squamous Cell Carcinoma. 2022 2
25 35188360 The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer. 2022 Feb 22 1
26 35216325 A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids. 2022 Feb 17 3
27 35235599 Cell-penetrating peptides containing the progesterone receptor polyproline domain inhibits EGF signaling and cell proliferation in lung cancer cells. 2022 3
28 35240162 PTPIP51 inhibits non-small-cell lung cancer by promoting PTEN-mediated EGFR degradation. 2022 May 15 1
29 35303882 Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression. 2022 Mar 18 1
30 35305596 Rationale and design of a phase II trial of dacomitinib in advanced non-small cell lung cancer patients with uncommon epidermal growth factor receptor mutations: a prospective and single arm study (DANCE study). 2022 Mar 19 1
31 35319011 MiR-323a regulates ErbB3/EGFR and blocks gefitinib resistance acquisition in colorectal cancer. 2022 Mar 22 3
32 35326664 Early On-Treatment Prediction of the Mechanisms of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors. 2022 Mar 15 1
33 35330996 Co-treatment of betulin and gefitinib is effective against EGFR wild-type/KRAS-mutant non-small cell lung cancer by inducing ferroptosis. 2022 May 5
34 35360423 Treatment Effectiveness and Tolerability of Long-term Adjuvant First- and Second-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor at Different Doses in Patients With Stage IIA-IIIB Epidermal Growth Factor Receptor-Mutated Lung Adenocarcinoma: A Retrospective Study. 2022 1
35 35399718 An insulin growth factor-I/II-neutralizing monoclonal antibody in combination with epidermal growth factor receptor inhibitors potently inhibits tumor cell growth. 2022 1
36 35399731 LPCAT1 promotes gefitinib resistance via upregulation of the EGFR/PI3K/AKT signaling pathway in lung adenocarcinoma. 2022 3
37 35402377 Combining EGFR-TKI With SAHA Overcomes EGFR-TKI-Acquired Resistance by Reducing the Protective Autophagy in Non-Small Cell Lung Cancer. 2022 2
38 35408854 Hybrid Pharmacophore- and Structure-Based Virtual Screening Pipeline to Identify Novel EGFR Inhibitors That Suppress Non-Small Cell Lung Cancer Cell Growth. 2022 Mar 23 1
39 35433830 Recombinant Prolidase Activates EGFR-Dependent Cell Growth in an Experimental Model of Inflammation in HaCaT Keratinocytes. Implication for Wound Healing. 2022 1
40 35433927 An advanced non-small cell lung cancer patient with EGFR and KRAS mutations, and PD-L1 positive, benefited from immunotherapy: a case report. 2022 Mar 1
41 35445730 EGFR inhibition reverses epithelial‑mesenchymal transition, and decreases tamoxifen resistance via Snail and Twist downregulation in breast cancer cells. 2022 Jun 1
42 35446957 First-line therapy in non-small cell lung cancer patients with EGFR activating mutations: a consideration of the clinical position of osimertinib based on the subset of Japanese patients in the FLAURA study. 2022 Apr 22 1
43 35462930 Acquired Concurrent EGFR T790M and Driver Gene Resistance From EGFR-TKIs Hampered Osimertinib Efficacy in Advanced Lung Adenocarcinoma: Case Reports. 2022 2
44 35463301 Bruceine H Mediates EGFR-TKI Drug Persistence in NSCLC by Notch3-Dependent β-Catenin Activating FOXO3a Signaling. 2022 4
45 35468939 CRL2KLHDC3 mediates p14ARF N-terminal ubiquitylation degradation to promote non-small cell lung carcinoma progression. 2022 May 2
46 35478210 Decoy receptor 3 is involved in epidermal keratinocyte commitment to terminal differentiation via EGFR and PKC activation. 2022 Apr 1
47 35481881 Targeted Drug/Gene/Photodynamic Therapy via a Stimuli-Responsive Dendritic-Polymer-Based Nanococktail for Treatment of EGFR-TKI-Resistant Non-Small-Cell Lung Cancer. 2022 Apr 28 1
48 35488047 Proton pump inhibitors reduce the survival of advanced lung cancer patients with therapy of gefitinib or erlotinib. 2022 Apr 29 1
49 35522668 The efficacy of T790M mutation testing in liquid biopsy-Real clinic data. 2022 1
50 35530301 Meclofenamic Acid Restores Gefinitib Sensitivity by Downregulating Breast Cancer Resistance Protein and Multidrug Resistance Protein 7 via FTO/m6A-Demethylation/c-Myc in Non-Small Cell Lung Cancer. 2022 3