| 1 |
29324220 | 5-fluorouracil Toxicity Mechanism Determination in Human Keratinocytes: in vitro Study on HaCaT Cell Line. | 2017 |
1 |
| 2 |
23494117 | Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase. | 2014 Jan |
1 |
| 3 |
24093908 | Targeting thymidylate synthase in colorectal cancer: critical re-evaluation and emerging therapeutic role of raltitrexed. | 2014 Jan |
1 |
| 4 |
25453619 | Phase II clinical trial of S-1 plus oral leucovorin in previously treated patients with non-small-cell lung cancer. | 2014 Dec |
1 |
| 5 |
20567941 | Severe toxicity of capecitabine following uncomplicated treatment with 5-fluorouracil/leucovorin. | 2011 Dec |
1 |
| 6 |
20647221 | Associations of various gene polymorphisms with toxicity in colorectal cancer patients receiving oral uracil and tegafur plus leucovorin: a prospective study. | 2011 Feb |
2 |
| 7 |
20372793 | The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells. | 2010 May |
3 |
| 8 |
15638735 | Novel chemical strategies for thymidylate synthase inhibition. | 2005 |
3 |
| 9 |
16077970 | Thymidylate synthase expression levels: a prognostic and predictive role in advanced colorectal cancer. | 2005 Sep |
1 |
| 10 |
15025795 | Dihydropyrimidine dehydrogenase and thymidylate synthase polymorphisms and their association with 5-fluorouracil/leucovorin chemotherapy in colorectal cancer. | 2004 Feb |
1 |
| 11 |
12610179 | Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites. | 2003 Mar 1 |
3 |
| 12 |
12084461 | Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. | 2002 Jul 18 |
2 |
| 13 |
12422306 | The role of oxaliplatin in the treatment of advanced metastatic colorectal cancer: prospects and future directions. | 2002 Oct |
1 |
| 14 |
12453856 | Thymidylate synthase protein expression in colorectal cancer metastases predicts for clinical outcome to leucovorin-modulated bolus or infusional 5-fluorouracil but not methotrexate-modulated bolus 5-fluorouracil. | 2002 Dec |
1 |
| 15 |
11274973 | Cytotoxic synergism of methioninase in combination with 5-fluorouracil and folinic acid. | 2001 Apr 1 |
1 |
| 16 |
11283924 | Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma. | 2001 Apr 1 |
1 |
| 17 |
12445371 | Chemotherapeutic strategies for treatment of colorectal cancer: present and future developments. | 2001 Aug |
1 |
| 18 |
10097740 | [Leucovorin and 5-FU for advanced gastrointestinal cancer]. | 1999 Mar |
2 |
| 19 |
10473077 | Thymidylate synthase protein expression in advanced colon cancer: correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil. | 1999 Aug |
1 |
| 20 |
9596684 | Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843. | 1998 Jun 1 |
2 |
| 21 |
9663808 | Clinically relevant drug-drug interactions in oncology. | 1998 Jun |
1 |
| 22 |
9726090 | Thymidylate synthase as a predictor of response. | 1998 Aug |
1 |
| 23 |
9796967 | High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil. | 1998 Oct |
2 |
| 24 |
8996166 | Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors. | 1997 Jan |
4 |
| 25 |
9223329 | Thymineless death in colon carcinoma cells is mediated via fas signaling. | 1997 Jul 22 |
1 |
| 26 |
9336359 | Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. | 1997 Oct |
1 |
| 27 |
9620216 | 5-fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man. | 1997 |
3 |
| 28 |
8765432 | Thymidylate synthase inhibition by an oral regimen consisting of tegafur-uracil (UFT) and low-dose leucovorin for patients with gastric cancer. | 1996 |
2 |
| 29 |
9816097 | Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma. | 1996 Jan |
1 |
| 30 |
7574773 | [Pharmacological and biochemical investigation of intracavital fluorinated pyrimidine chemotherapy]. | 1995 Sep |
1 |
| 31 |
7575641 | Studies on the antitumor effects of analogues of 5,8-dideazaisofolic acid and 5,8-dideazaisoaminopterin. | 1995 Sep 7 |
1 |
| 32 |
7577040 | Thymidylate synthase and drug resistance. | 1995 Jul-Aug |
1 |
| 33 |
7577041 | Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: preliminary report from an ongoing trial. | 1995 Jul-Aug |
1 |
| 34 |
7779703 | The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells. | 1995 Jun |
18 |
| 35 |
7805178 | Phase I study of phosphonacetyl-L-aspartate, 5-fluorouracil, and leucovorin in patients with advanced cancer. | 1995 |
2 |
| 36 |
7882343 | Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. | 1995 Apr 1 |
2 |
| 37 |
7518280 | New targets for pyrimidine antimetabolites in the treatment of solid tumours. 1: Thymidylate synthase. | 1994 Apr 15 |
1 |
| 38 |
7872700 | Thymidylate synthase levels in tumor biopsies from patients with colorectal cancer. | 1994 Nov-Dec |
2 |
| 39 |
7931471 | Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. | 1994 Oct |
1 |
| 40 |
8053928 | Down-regulation of c-myc gene expression with induction of high molecular weight DNA fragments by fluorodeoxyuridine. | 1994 Jul 19 |
1 |
| 41 |
8141112 | Phase II trial of 5-fluorouracil and high-dose folinic acid as first- or second-line therapy for advanced breast cancer. | 1994 Apr |
1 |
| 42 |
8178733 | Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase. | 1993 |
1 |
| 43 |
8304192 | Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent. | 1993 |
1 |
| 44 |
8398636 | Leucovorin modulation of fluorouracil. | 1993 Aug |
1 |
| 45 |
8400344 | Immunological quantitation of thymidylate synthase-FdUMP-5,10-methylenetetrahydrofolate ternary complex with the monoclonal antibody TS 106. | 1993 Aug |
1 |
| 46 |
8461049 | Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase. | 1993 Mar 9 |
2 |
| 47 |
8500227 | Phase I trial of a 5-day infusion of L-leucovorin plus daily bolus 5-fluorouracil in patients with advanced gastrointestinal malignancies. | 1993 |
1 |
| 48 |
1327567 | In vitro enhancement of fluoropyrimidine-induced cytotoxicity by leucovorin in colorectal and gastric carcinoma cell lines but not in non-small-cell lung carcinoma cell lines. | 1992 |
2 |
| 49 |
1557655 | Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. | 1992 Apr |
1 |
| 50 |
1596583 | Quantitation of dihydrofolate reductase and thymidylate synthase mRNAs in vivo and in vitro by polymerase chain reaction. | 1992 |
2 |