Caffeine

ATM serine/threonine kinase ; Homo sapiens







99 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 33971260 Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes. 2021 Jun 15 5
2 34043345 Bavachinin Induces G2/M Cell Cycle Arrest and Apoptosis via the ATM/ATR Signaling Pathway in Human Small Cell Lung Cancer and Shows an Antitumor Effect in the Xenograft Model. 2021 Jun 9 1
3 33101488 Small molecule 2,3-DCPE induces S phase arrest by activating the ATM/ATR-Chk1-Cdc25A signaling pathway in DLD-1 colon cancer cells. 2020 Dec 2
4 31168028 Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells. 2019 1
5 28986085 Ovatodiolide isolated from Anisomeles indica induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways. 2018 Jan 15 1
6 29923368 Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. 2018 Aug 1
7 26683224 Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. 2016 Jan 26 1
8 26727128 Checkpoint Kinase 1 Activation Enhances Intestinal Epithelial Barrier Function via Regulation of Claudin-5 Expression. 2016 2
9 26965143 Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. 2016 May 2
10 25812484 Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces G₂/M cell cycle arrest through the activation of ATM/ATR in human cervical carcinoma HeLa cells. 2015 May 1
11 25872745 Hepatitis B virus X protein activates the ATM-Chk2 pathway and delays cell cycle progression. 2015 Aug 2
12 26521794 Caffeine Suppresses Apoptosis of Bladder Cancer RT4 Cells in Response to Ionizing Radiation by Inhibiting Ataxia Telangiectasia Mutated-Chk2-p53 Axis. 2015 Nov 5 4
13 26556501 Effect of ATM and HDAC Inhibition on Etoposide-Induced DNA Damage in Porcine Early Preimplantation Embryos. 2015 1
14 26649750 Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia. 2015 2
15 23515941 Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro. 2013 Oct 2
16 23705030 Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. 2013 3
17 21964066 The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function. 2012 Jan 2
18 21984412 Phosphorylation of SRSF1 is modulated by replicational stress. 2012 Feb 1
19 22593008 E2F1-dependent pathways are involved in amonafide analogue 7-d-induced DNA damage, G2/M arrest, and apoptosis in p53-deficient K562 cells. 2012 Oct 2
20 23096362 Response of the G2-prophase checkpoint to genotoxic drugs in lymphocytes from healthy individuals. 2012 1
21 20888899 Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK. 2011 Feb 1
22 21325885 Three independent mechanisms for arrest in G2 after ionizing radiation. 2011 Mar 1 1
23 21424556 Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells. 2011 May 1
24 21425328 Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway. 2011 Sep 1
25 21518729 ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance. 2011 Jun 1
26 21526346 Curcumin induces DNA damage and caffeine-insensitive cell cycle arrest in colorectal carcinoma HCT116 cells. 2011 Aug 3
27 21631964 The effect of ATM and ERK1/2 inhibition on mitoxantrone-induced cell death of leukaemic cells. 2011 2
28 21945951 The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases. 2011 Nov-Dec 1
29 19926122 Influence of TEGDMA on the mammalian cell cycle in comparison with chemotherapeutic agents. 2010 Mar 1
30 20028385 Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis. 2010 Mar 1
31 20734998 Proliferation inhibition, DNA damage, and cell-cycle arrest of human astrocytoma cells after acrylamide exposure. 2010 Sep 20 1
32 20861183 Evidence of an adaptive response targeting DNA nonhomologous end joining and its transmission to bystander cells. 2010 Nov 1 1
33 19098271 ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. 2009 Apr 9 1
34 19261750 Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. 2009 Jun 1
35 19296337 Stress response of a p53 homologue in the radioresistant Sf9 insect cells. 2009 Mar 2
36 19297526 Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage. 2009 May 1
37 19305423 Induction of G2/M arrest by pseudolaric acid B is mediated by activation of the ATM signaling pathway. 2009 Apr 1
38 19324081 Coactivation of ATM/ERK/NF-kappaB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes. 2009 Jun 1 1
39 19414815 Proteasome regulation of ULBP1 transcription. 2009 May 15 2
40 19536869 Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells. 2009 Jul 1
41 19705844 Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma mcf-7 cells by blocking cell cycle progression and inducing apoptosis. 2009 Sep 23 1
42 19738435 Cancer stem cells and escape from drug-induced premature senescence in human lung tumor cells: implications for drug resistance and in vitro drug screening models. 2009 Oct 1 1
43 19881958 Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. 2009 Nov 2
44 19903334 The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. 2009 Nov 10 1
45 17594092 Caffeine markedly sensitizes human mesothelioma cell lines to pemetrexed. 2008 Apr 2
46 17932622 Caffeine inhibits UV-mediated NF-kappaB activation in A2058 melanoma cells: an ATM-PKCdelta-p38 MAPK-dependent mechanism. 2008 Jan 2
47 18207464 ATM mediates repression of DNA end-degradation in an ATP-dependent manner. 2008 Mar 1 1
48 18223691 p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. 2008 Jun 5 1
49 18247328 Involvement of the role of Chk1 in lithium-induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells. 2008 Jul 1 1
50 18440285 Sustained activation of p53 in confluent nucleotide excision repair-deficient cells resistant to ultraviolet-induced apoptosis. 2008 Jun 1 1