Dantrolene

ryanodine receptor 1 ; Homo sapiens







35 Article(s)
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1 34348614 RYR1-Related Rhabdomyolysis: A Spectrum of Hypermetabolic States Due to Ryanodine Receptor Dysfunction. 2022 2
2 35144690 Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion. 2022 Feb 11 1
3 35549722 The effects of dantrolene in the presence or absence of ryanodine receptor type 1 variants in individuals predisposed to malignant hyperthermia. 2022 Jul 3
4 31192224 Entrainment of Circadian Rhythms to Temperature Reveals Amplitude Deficits in Fibroblasts from Patients with Bipolar Disorder and Possible Links to Calcium Channels. 2019 Apr 1
5 31299492 Structural development of a type-1 ryanodine receptor (RyR1) Ca2+-release channel inhibitor guided by endoplasmic reticulum Ca2+ assay. 2019 Oct 1 1
6 31337666 Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor. 2019 Sep 9
7 29237755 Differential contribution of Ca2+ sources to day and night BK current activation in the circadian clock. 2018 Feb 5 2
8 29772645 Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells. 2018 May 16 2
9 28322744 Basal ryanodine receptor activity suppresses autophagic flux. 2017 May 15 1
10 28568606 Coupling of excitation to Ca2+ release is modulated by dysferlin. 2017 Aug 1 1
11 28687594 Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease. 2017 Aug 7 2
12 29214114 Calcium Dysregulation in Alzheimer's Disease: A Target for New Drug Development. 2017 Aug 2
13 27382027 An RYR1 mutation associated with malignant hyperthermia is also associated with bleeding abnormalities. 2016 Jul 5 2
14 27431030 Dantrolene as a possible prophylactic treatment for RYR1-related rhabdomyolysis. 2016 Aug 1
15 27544065 Nitric Oxide-induced Activation of the Type 1 Ryanodine Receptor Is Critical for Epileptic Seizure-induced Neuronal Cell Death. 2016 Sep 1
16 27717822 Inhibiting c-Jun N-terminal kinase partially attenuates caffeine-dependent cell death without alleviating the caffeine-induced reduction in mitochondrial respiration in C2C12 skeletal myotubes. 2016 Nov 4 2
17 27812757 Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3). 2016 Nov 1
18 24861510 Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. 2014 Jul 11 1
19 21262961 Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. 2011 Apr 8 3
20 21291389 The ryanodine receptor: a pivotal Ca2+ regulatory protein and potential therapeutic drug target. 2011 May 1
21 20962236 Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax. 2010 Oct 20 1
22 19636685 Effects of small molecule modulators on ATP binding to skeletal ryanodine receptor. 2009 Jun 2
23 19651767 The Qgamma component of intra-membrane charge movement is present in mammalian muscle fibres, but suppressed in the absence of S100A1. 2009 Sep 15 1
24 17707769 Identification of functional type 1 ryanodine receptors in human dendritic cells. 2007 Oct 19 2
25 16751979 Modulation of store-operated Ca2+ entry by cyclic-ADP-ribose. 2006 Jun 1
26 16945924 Azumolene inhibits a component of store-operated calcium entry coupled to the skeletal muscle ryanodine receptor. 2006 Nov 3 1
27 15677376 Postulated role of interdomain interactions within the type 1 ryanodine receptor in the low gain of Ca2+-induced Ca2+ release activity of mammalian skeletal muscle sarcoplasmic reticulum. 2005 Jun 1
28 15160398 Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide. 2004 Jun 15 1
29 15299003 Effect of ryanodine receptor mutations on interleukin-6 release and intracellular calcium homeostasis in human myotubes from malignant hyperthermia-susceptible individuals and patients affected by central core disease. 2004 Oct 15 2
30 12566385 Clinical and functional effects of a deletion in a COOH-terminal lumenal loop of the skeletal muscle ryanodine receptor. 2003 Feb 15 1
31 12167662 Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. 2002 Sep 20 6
32 11278295 Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. 2001 Apr 27 8
33 11741831 Identification of four novel mutations in the C-terminal membrane spanning domain of the ryanodine receptor 1: association with central core disease and alteration of calcium homeostasis. 2001 Dec 1 2
34 10603942 Potential for pharmacology of ryanodine receptor/calcium release channels. 1998 Sep 16 1
35 9307036 Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle. 1997 Sep 15 4