| 1 |
32830360 | Membrane dynamics of γ-secretase with the anterior pharynx-defective 1B subunit. | 2021 Jan |
3 |
| 2 |
33373587 | Structural basis of γ-secretase inhibition and modulation by small molecule drugs. | 2021 Jan 21 |
1 |
| 3 |
34603012 | Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease. | 2021 |
1 |
| 4 |
32420742 | Identification of Structural Calcium Binding Sites in Membrane-Bound Presenilin 1 and 2. | 2020 Jun 11 |
1 |
| 5 |
27836335 | A novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer's disease. | 2017 Feb |
1 |
| 6 |
25918421 | Structural basis of human γ-secretase assembly. | 2015 May 12 |
1 |
| 7 |
25329837 | In silico screening of drugs to find potential gamma-secretase inhibitors using pharmacophore modeling, QSAR and molecular docking studies. | 2014 |
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| 8 |
18393802 | From presenilinase to gamma-secretase, cleave to capacitate. | 2008 Apr |
3 |
| 9 |
15797863 | Presenilin-1 D257A and D385A mutants fail to cleave Notch in their endoproteolyzed forms, but only presenilin-1 D385A mutant can restore its gamma-secretase activity with the compensatory overexpression of normal C-terminal fragment. | 2005 Jun 10 |
1 |
| 10 |
12147673 | Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. | 2002 Aug 5 |
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| 11 |
11551913 | Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations. | 2001 Nov 16 |
2 |
| 12 |
11593035 | PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling. | 2001 Oct 9 |
6 |
| 13 |
10652302 | The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. | 2000 Feb 4 |
5 |
| 14 |
10783238 | Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. | 2000 Apr |
5 |
| 15 |
10856299 | Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes. | 2000 Sep 1 |
3 |
| 16 |
11056541 | Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. | 2000 Nov |
1 |
| 17 |
11114265 | FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. | 2000 Dec |
1 |
| 18 |
11261807 | Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes. | 2000 |
2 |
| 19 |
10593990 | Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. | 1999 Dec 17 |
2 |
| 20 |
8931704 | A novel mutation of presenilin 1 in familial Alzheimer's disease in Israel detected by denaturing gradient gel electrophoresis. | 1996 Dec |
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