Glutathione

glutathione S-transferase alpha 1 ; Homo sapiens







92 Article(s)
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1 34990437 Impact of Glutathione S-transferase Polymorphisms on Busulfan Pharmacokinetics and Outcomes of Hematopoietic Stem Cell Transplantation. 2022 Jan 4 1
2 35344726 Role of human salivary enzymes in bitter taste perception. 2022 Aug 30 1
3 32661806 Influence of glutathione S transferase A1 gene polymorphism (-69C > T, rs3957356) on intravenous cyclophosphamide efficacy and side effects: a case-control study in Egyptian patients with lupus nephritis. 2021 Feb 1
4 34988113 GSTP1 and GSTM3 Variant Alleles Affect Susceptibility and Severity of COVID-19. 2021 1
5 32021204 Effects of GSTA1 and GPX3 Polymorphisms on the Risk of Schizophrenia in Chinese Han Population. 2020 2
6 32713331 The Interaction of the Microtubule Targeting Anticancer Drug Colchicine with Human Glutathione Transferases. 2020 1
7 32822468 Interactions Between Odorants and Glutathione Transferases in the Human Olfactory Cleft. 2020 Nov 7 1
8 33035518 Activation of the Aryl Hydrocarbon Receptor (AHR) induces human glutathione S transferase alpha 1 (hGSTA1) expression. 2020 Nov 1 1
9 31681027 Autism Spectrum Disorders and Perinatal Complications-Is Oxidative Stress the Connection? 2019 1
10 30370843 A Microplate-based Platform with Immobilized Human Glutathione Transferase A1-1 for High-throughput Screening of Plant-origin Inhibitors. 2018 2
11 27612661 Directed evolution of glutathione transferases towards a selective glutathione-binding site and improved oxidative stability. 2017 Jan 2
12 26959016 Identification of Toxic Pyrrolizidine Alkaloids and Their Common Hepatotoxicity Mechanism. 2016 Mar 7 4
13 27183920 Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. 2016 Jul 25 1
14 27485632 Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells. 2016 Sep 1
15 27684484 Irreversible Inhibition of Glutathione S-Transferase by Phenethyl Isothiocyanate (PEITC), a Dietary Cancer Chemopreventive Phytochemical. 2016 1
16 27936036 The rs3957357C>T SNP in GSTA1 Is Associated with a Higher Risk of Occurrence of Hepatocellular Carcinoma in European Individuals. 2016 1
17 27989146 Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation. 2016 Dec 19 1
18 26278353 The busulfan metabolite EdAG irreversibly glutathionylates glutaredoxins. 2015 Oct 1 1
19 26554337 Benzene oxide is a substrate for glutathione S-transferases. 2015 Dec 5 1
20 25111321 Is increased susceptibility to Balkan endemic nephropathy in carriers of common GSTA1 (*A/*B) polymorphism linked with the catalytic role of GSTA1 in ochratoxin a biotransformation? Serbian case control study and in silico analysis. 2014 Aug 8 1
21 23460799 The interaction of the chemotherapeutic drug chlorambucil with human glutathione transferase A1-1: kinetic and structural analysis. 2013 4
22 24083800 Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac. 2013 Nov 18 1
23 22906494 The effect of menadione on glutathione S-transferase A1 (GSTA1): c-Jun N-terminal kinase (JNK) complex dissociation in human colonic adenocarcinoma Caco-2 cells. 2012 Oct 2 1
24 20857431 Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity. 2011 Apr 2
25 21530499 Analysis of human glutathione S-transferase alpha 1 (hGSTA1) gene promoter polymorphism using denaturing high performance liquid chromatography (DHPLC). 2011 Jul 15 1
26 21730282 Busulfan and metronidazole: an often forgotten but significant drug interaction. 2011 Jul 1
27 21914835 Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone. 2011 Dec 1
28 20052987 Glutathione transferase A1-1: catalytic importance of arginine 15. 2010 Feb 4 1
29 20085333 Substrate specificity combined with stereopromiscuity in glutathione transferase A4-4-dependent metabolism of 4-hydroxynonenal. 2010 Feb 23 1
30 20207535 GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis. 2010 Jun 1
31 20836986 Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal. 2010 Dec 15 4
32 20849150 Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine. 2010 Sep 20 3
33 19639209 The role of GSTA2 polymorphisms and haplotypes in breast cancer susceptibility: a case-control study in the Portuguese population. 2009 Sep 1
34 18791061 Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1. 2008 Dec 2
35 17561509 Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases. 2007 Aug 10 1
36 17594497 X-ray structures of Na-GST-1 and Na-GST-2 two glutathione S-transferase from the human hookworm Necator americanus. 2007 Jun 26 2
37 16608922 Chemical inducers of rodent glutathione s-transferases down-regulate human GSTA1 transcription through a mechanism involving variant hepatic nuclear factor 1-C. 2006 Jul 1
38 16616895 Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria. 2006 May 28 1
39 16782969 Stillbirth and slow metabolizers of caffeine: comparison by genotypes. 2006 Aug 2
40 16890185 Glutathione S-transferases as antioxidant enzymes: small cell lung cancer (H69) cells transfected with hGSTA1 resist doxorubicin-induced apoptosis. 2006 Aug 15 4
41 15829614 Genotoxicity of 4-hydroxy-2-nonenal in human colon tumor cells is associated with cellular levels of glutathione and the modulation of glutathione S-transferase A4 expression by butyrate. 2005 Jul 1
42 16082503 Potent isozyme-selective inhibition of human glutathione S-transferase A1-1 by a novel glutathione S-conjugate. 2005 Nov 1
43 16399377 Human alpha class glutathione S-transferases: genetic polymorphism, expression, and susceptibility to disease. 2005 1
44 14569069 Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. 2004 Jan 1
45 15103050 Biotransformation of methyl parathion by glutathione S-transferases. 2004 Jun 1
46 15274625 Structural basis for catalytic differences between alpha class human glutathione transferases hGSTA1-1 and hGSTA2-2 for glutathione conjugation of environmental carcinogen benzo[a]pyrene-7,8-diol-9,10-epoxide. 2004 Aug 3 4
47 15607759 Estradiol metabolites as isoform-specific inhibitors of human glutathione S-transferases. 2004 Dec 30 1
48 12516103 Association between a glutathione S-transferase A1 promoter polymorphism and survival after breast cancer treatment. 2003 Mar 1 1
49 12637518 The anomalous pKa of Tyr-9 in glutathione S-transferase A1-1 catalyzes product release. 2003 May 23 1
50 14690442 Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions. 2003 Dec 30 2