| 1 |
35184041 | Distinct roles of the sister nuclear receptors PXR and CAR in liver cancer development. | 2022 Feb 19 |
2 |
| 2 |
35367211 | Human constitutive androstane receptor represses liver cancer development and hepatoma cell proliferation by inhibiting erythropoietin signaling. | 2022 May |
1 |
| 3 |
34943889 | Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes. | 2021 Dec 1 |
7 |
| 4 |
31924695 | Ser100-Phosphorylated RORα Orchestrates CAR and HNF4α to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6. | 2020 Mar |
8 |
| 5 |
32788213 | Nuclear receptor phosphorylation in xenobiotic signal transduction. | 2020 Nov 6 |
4 |
| 6 |
32892155 | Antiepileptic Drug-Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator-Activated Receptor α and Peroxisome Proliferator-Activated Receptor γ Coactivator 1α-Dependent Gene Expression to Increase Blood Triglyceride Levels. | 2020 Nov |
1 |
| 7 |
33551819 | Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR). | 2020 |
1 |
| 8 |
30361333 | Constitutive androstane receptor 1 is constitutively bound to chromatin and 'primed' for transactivation in hepatocytes. | 2019 Jan |
2 |
| 9 |
31202736 | Indirect activation of constitutive androstane receptor in three-dimensionally cultured HepG2 cells. | 2019 Oct |
3 |
| 10 |
31436536 | Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor. | 2019 Sep |
6 |
| 11 |
31673501 | Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model. | 2019 |
1 |
| 12 |
29269410 | Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor. | 2018 Mar |
2 |
| 13 |
28062541 | Evaluation of a Novel Renewable Hepatic Cell Model for Prediction of Clinical CYP3A4 Induction Using a Correlation-Based Relative Induction Score Approach. | 2017 Feb |
1 |
| 14 |
28356313 | Phenobarbital Meets Phosphorylation of Nuclear Receptors. | 2017 May |
1 |
| 15 |
29219065 | Transactivation Assays that Identify Indirect and Direct Activators of Human Pregnane X Receptor (PXR, NR1I2) and Constitutive Androstane Receptor (CAR, NR1I3). | 2017 |
1 |
| 16 |
27074912 | p38 MAP Kinase Links CAR Activation and Inactivation in the Nucleus via Phosphorylation at Threonine 38. | 2016 Jun |
1 |
| 17 |
27155371 | Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics. | 2016 Jul 15 |
3 |
| 18 |
27338863 | Contextualizing Hepatocyte Functionality of Cryopreserved HepaRG Cell Cultures. | 2016 Sep |
1 |
| 19 |
27530964 | Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation. | 2016 Oct |
2 |
| 20 |
25625231 | Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR). | 2015 Mar 4 |
1 |
| 21 |
25975989 | Regulation of gene expression by CAR: an update. | 2015 Jul |
2 |
| 22 |
24180433 | Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. | 2014 Jan |
4 |
| 23 |
24224465 | Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. | 2014 Feb 15 |
2 |
| 24 |
24690595 | Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors. | 2014 Jun |
1 |
| 25 |
24789201 | Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system. | 2014 |
7 |
| 26 |
23652203 | Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling. | 2013 May 7 |
4 |
| 27 |
22093699 | Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes. | 2012 Jan 15 |
2 |
| 28 |
22101211 | Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase. | 2012 Jan 25 |
2 |
| 29 |
22761658 | Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. | 2012 |
1 |
| 30 |
22815988 | MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. | 2012 |
4 |
| 31 |
21872825 | Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines. | 2011 Jul |
5 |
| 32 |
20185760 | Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). | 2010 Apr |
1 |
| 33 |
20645062 | Metabonomic studies on human hepatocyte in primary culture. | 2010 |
2 |
| 34 |
20871212 | Estrogen modulates transactivations of SXR-mediated liver X receptor response element and CAR-mediated phenobarbital response element in HepG2 cells. | 2010 Nov 30 |
2 |
| 35 |
19541828 | Genetic polymorphisms in the TATA box and upstream phenobarbital-responsive enhancer module of the UGT1A1 promoter have combined effects on UDP-glucuronosyltransferase 1A1 transcription mediated by constitutive androstane receptor, pregnane X receptor, or glucocorticoid receptor in human liver. | 2009 Sep |
1 |
| 36 |
18172616 | Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter. | 2008 Jun |
2 |
| 37 |
18332078 | Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. | 2008 Jun |
1 |
| 38 |
18332083 | ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses. | 2008 Jun |
1 |
| 39 |
17888866 | Regulation of the human cathepsin E gene by the constitutive androstane receptor. | 2007 Nov 1 |
2 |
| 40 |
16623664 | Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. | 2006 Aug 15 |
2 |
| 41 |
16635107 | Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR. | 2006 May |
1 |
| 42 |
16725103 | Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2. | 2006 Jul 15 |
4 |
| 43 |
17341620 | Effects of TK promotor and hepatocyte nuclear factor-4 in CAR-mediated transcriptional activity of phenobarbital responsive unit of CYP2B gene in monkey kidney epithelial-derived cell line COS-7. | 2006 Dec |
1 |
| 44 |
15557560 | Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1. | 2005 Mar |
2 |
| 45 |
15591315 | Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation. | 2005 Feb 25 |
5 |
| 46 |
15802384 | Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. | 2005 Jul |
1 |
| 47 |
15832810 | Induction of phase I, II and III drug metabolism/transport by xenobiotics. | 2005 Mar |
3 |
| 48 |
16101572 | CAR, the continuously advancing receptor, in drug metabolism and disease. | 2005 Aug |
4 |
| 49 |
15000748 | Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP). | 2004 Feb |
5 |
| 50 |
15043764 | Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor. | 2004 Mar 25 |
2 |