| 1 |
34860252 | pVHL-mediated SMAD3 degradation suppresses TGF-β signaling. | 2022 Jan 3 |
1 |
| 2 |
35505422 | VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells. | 2022 May 3 |
1 |
| 3 |
34537235 | HIF-1α Hydroxyprolines Modulate Oxygen-Dependent Protein Stability Via Single VHL Interface With Comparable Effect on Ubiquitination Rate. | 2021 Nov 5 |
1 |
| 4 |
32023483 | Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss. | 2020 Mar 19 |
1 |
| 5 |
32640193 | Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation. | 2020 Aug 6 |
1 |
| 6 |
31035491 | Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous? | 2019 Apr 26 |
2 |
| 7 |
27902963 | Homology modeling and molecular dynamics simulation of the HIF2α degradation-related HIF2α-VHL complex. | 2017 Jan |
1 |
| 8 |
26972007 | The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. | 2016 Mar 22 |
1 |
| 9 |
27563096 | pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. | 2016 Aug 26 |
1 |
| 10 |
24563687 | Proline-hydroxylated hypoxia-inducible factor 1α (HIF-1α) upregulation in human tumours. | 2014 |
3 |
| 11 |
22649785 | The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer. | 2012 |
1 |
| 12 |
20978146 | von Hippel-Lindau-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas. | 2010 Nov 1 |
1 |
| 13 |
19151537 | Drug discovery for overcoming chronic kidney disease (CKD): prolyl-hydroxylase inhibitors to activate hypoxia-inducible factor (HIF) as a novel therapeutic approach in CKD. | 2009 Jan |
1 |
| 14 |
19584355 | Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. | 2009 Jul 7 |
2 |
| 15 |
17942596 | Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. | 2008 Jan |
1 |
| 16 |
18285459 | The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress. | 2008 Apr |
1 |
| 17 |
18694926 | Identification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alpha. | 2008 Oct 24 |
4 |
| 18 |
17189520 | Hypoxia-inducible factors in the first trimester human lung. | 2007 Apr |
1 |
| 19 |
17551816 | HIF-1 mediates the Warburg effect in clear cell renal carcinoma. | 2007 Jun |
2 |
| 20 |
17579185 | A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove. | 2007 Sep 15 |
2 |
| 21 |
16509823 | Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation. | 2006 Jul 1 |
1 |
| 22 |
15084514 | Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation. | 2004 Jun |
1 |
| 23 |
12393546 | Mutations in the VHL gene in sporadic apparently congenital polycythemia. | 2003 Feb 15 |
1 |
| 24 |
12604794 | von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. | 2003 Mar 4 |
1 |
| 25 |
12004076 | Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. | 2002 Jun 7 |
1 |
| 26 |
12205091 | Leu-574 of HIF-1alpha is essential for the von Hippel-Lindau (VHL)-mediated degradation pathway. | 2002 Nov 1 |
2 |
| 27 |
11292861 | Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. | 2001 Apr 20 |
1 |
| 28 |
11292862 | HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. | 2001 Apr 20 |
2 |
| 29 |
11504942 | HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. | 2001 Aug 14 |
2 |