Chloroquine

AKT serine/threonine kinase 1 ; Homo sapiens







24 Article(s)
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1 34653791 Melatonin mitigates Chloroquine-induced defects in porcine immature Sertoli cells. 2022 Jan 1 1
2 32990544 Palladium (II) Complex Enhances ROS-Dependent Apoptotic Effects via Autophagy Inhibition and Disruption of Multiple Signaling Pathways in Colorectal Cancer Cells. 2021 2
3 33799790 Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells. 2021 Mar 11 2
4 34229754 Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α-AKT-mTOR pathway in esophageal squamous cell carcinoma. 2021 Jul 6 4
5 34428517 Peroxiredoxin 1 is essential for natamycin-triggered apoptosis and protective autophagy in hepatocellular carcinoma. 2021 Aug 21 2
6 34771150 Chloroquine Potentiates the Anticancer Effect of Pterostilbene on Pancreatic Cancer by Inhibiting Autophagy and Downregulating the RAGE/STAT3 Pathway. 2021 Nov 8 1
7 32654071 Inhibition of autophagy by chloroquine enhances the antitumor activity of gemcitabine for gallbladder cancer. 2020 Aug 1
8 30767087 Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of β-catenin pathway. 2019 Jun 2
9 29435010 Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis. 2018 Mar 1
10 29658606 Chloroquine inhibits cell growth in human A549 lung cancer cells by blocking autophagy and inducing mitochondrial‑mediated apoptosis. 2018 Jun 1
11 28337019 Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling. 2017 Mar 23 1
12 27047993 Chloroquine increases phosphorylation of AMPK and Akt in myotubes. 2016 Mar 8
13 27779641 AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells. 2016 Dec 1
14 24946858 Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells. 2014 Jul 15 1
15 23258740 Blocked autophagy using lysosomotropic agents sensitizes resistant prostate tumor cells to the novel Akt inhibitor AZD5363. 2013 Feb 15 1
16 23530461 Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy. 2013 Jun 1
17 23702482 Chloroquine stimulates glucose uptake and glycogen synthase in muscle cells through activation of Akt. 2013 Jun 14 8
18 24287900 Blocking autophagic flux enhances matrine-induced apoptosis in human hepatoma cells. 2013 Nov 25 1
19 22142888 Akt and p53 are potential mediators of reduced mammary tumor growth by cloroquine and the mTOR inhibitor RAD001. 2012 Feb 15 4
20 23091617 Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote γ-irradiation-induced cell death in primary stem-like glioma cells. 2012 1
21 19945197 A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. 2010 Feb 3
22 18691894 The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. 2008 Sep 1 6
23 19088425 Cell growth inhibition, G2/M cell cycle arrest, and apoptosis induced by chloroquine in human breast cancer cell line Bcap-37. 2008 1
24 15382077 Enhancement of the p27Kip1-mediated antiproliferative effect of trastuzumab (Herceptin) on HER2-overexpressing tumor cells. 2004 Nov 10 1