Imatinib Mesylate

AKT serine/threonine kinase 1 ; Homo sapiens







109 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 34738628 Glucose transporter‑1 inhibition overcomes imatinib resistance in gastrointestinal stromal tumor cells. 2022 Jan 2
2 34820006 Tanshinone IIA potentiates the efficacy of imatinib by regulating the AKT-MDM2-P53 signaling pathway in Philadelphia chromosome-positive acute lymphoblastic leukemia. 2022 Jan 2
3 34822800 Imatinib mesylate inhibits androgen-independent PC-3 cell viability, proliferation, migration, and tumor growth by targeting platelet-derived growth factor receptor-α. 2022 Jan 1 1
4 35120552 GnRH antagonist weakens endometrial stromal cells growth ability by decreasing c-kit receptor expression. 2022 Feb 4 1
5 35183792 The synergistic therapeutic effect of Imatinib and Protein Kinase CK2 Inhibition correlates with PI3K-AKT activation in gastrointestinal stromal tumors. 2022 Feb 17 1
6 33289342 Sulfasalazine synergistically enhances the inhibitory effects of imatinib against hepatocellular carcinoma (HCC) cells by targeting NFκB, BCR/ABL, and PI3K/AKT signaling pathway-related proteins. 2021 Mar 1
7 33910311 [CRISPR/Cas9-mediated microRNA-21 knockout increased imatinib sensitivity in chronic myeloid leukemia cells]. 2021 Mar 14 1
8 34087223 Imatinib inhibits the malignancy of hepatocellular carcinoma by suppressing autophagy. 2021 Sep 5 1
9 34667163 BRD9 inhibition promotes PUMA-dependent apoptosis and augments the effect of imatinib in gastrointestinal stromal tumors. 2021 Oct 19 1
10 34843676 Simvastatin potentiates the cell-killing activity of imatinib in imatinib-resistant chronic myeloid leukemia cells mainly through PI3K/AKT pathway attenuation and Myc downregulation. 2021 Dec 15 2
11 34938656 Case Report: Long-Term Response to Radiotherapy Combined With Targeted Therapy in Histiocytic Sarcoma Harboring Mutations in MAPK and PI3K/AKT Pathways. 2021 1
12 31776458 Coordinated targeting of CK2 and KIT in gastrointestinal stromal tumours. 2020 Feb 1
13 32606967 Inhibition of Skp2 Sensitizes Chronic Myeloid Leukemia Cells to Imatinib. 2020 2
14 33022360 Imatinib exhibit synergistic pleiotropy in the prevention of colorectal cancer by suppressing proinflammatory, cell survival and angiogenic signaling. 2020 Dec 1
15 33040790 Effects of Twist1 on drug resistance of chronic myeloid leukemia cells through the PI3K/AKT signaling pathway. 2020 Sep 30 4
16 31138788 A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer. 2019 May 28 1
17 31233186 Knockdown of ribonucleotide reductase regulatory subunit M2 increases the drug sensitivity of chronic myeloid leukemia to imatinib‑based therapy. 2019 Aug 1
18 31493871 TAL1 mediates imatinib-induced CML cell apoptosis via the PTEN/PI3K/AKT pathway. 2019 Nov 5 1
19 29423045 Ovatodiolide targets chronic myeloid leukemia stem cells by epigenetically upregulating hsa-miR-155, suppressing the BCR-ABL fusion gene and dysregulating the PI3K/AKT/mTOR pathway. 2018 Jan 9 1
20 29552859 [Inhibitory effect and mechanism of platycodin D combined with imatinib on K562/R]. 2018 Jan 1
21 29623544 SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling. 2018 Nov 5
22 30671399 Anti-growth Effects of Imatinib and GNF5 via Regulation of Skp2 in Human Hepatocellular Carcinoma Cells. 2018 Dec 2
23 27370604 Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor. 2017 Jan 1 1
24 27718039 4-methylumbelliferone and imatinib combination enhances senescence induction in chronic myeloid leukemia cell lines. 2017 Feb 2
25 27875938 The role of long noncoding RNA HOTAIR in the acquired multidrug resistance to imatinib in chronic myeloid leukemia cells. 2017 May 3
26 28069548 Long noncoding RNA HULC promotes cell proliferation by regulating PI3K/AKT signaling pathway in chronic myeloid leukemia. 2017 Apr 5 2
27 28103766 Long-Term Exposure to Imatinib Mesylate Downregulates Hippo Pathway and Activates YAP in a Model of Chronic Myelogenous Leukemia. 2017 May 1 1
28 28403213 M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells. 2017 2
29 28442505 Overexpressed Fatty Acid Synthase in Gastrointestinal Stromal Tumors: Targeting a Progression-Associated Metabolic Driver Enhances the Antitumor Effect of Imatinib. 2017 Aug 15 1
30 28612529 [The Mechanism of Combination using mTORC1/2 Inhibitor and Imatinib to Suppress Cell Proliferation of Ph +ALL Cell Line]. 2017 Mar 1
31 28616912 [The Roles of Glut5 in Imatinib Resistance in the Ph+ Acute Lymphoblastic Leukemia Cell]. 2017 May 2
32 28962554 Propofol enhances BCR-ABL TKIs' inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression. 2017 Sep 29 2
33 28986256 MicroRNA-7 inhibits cell proliferation of chronic myeloid leukemia and sensitizes it to imatinib in vitro. 2017 Dec 9 1
34 29029406 Lyn mediates FIP1L1-PDGFRA signal pathway facilitating IL-5RA intracellular signal through FIP1L1-PDGFRA/JAK2/Lyn/Akt network complex in CEL. 2017 Sep 12 1
35 29046392 Nutlin-3 plus tanshinone IIA exhibits synergetic anti-leukemia effect with imatinib by reactivating p53 and inhibiting the AKT/mTOR pathway in Ph+ ALL. 2017 Dec 6 1
36 26893362 RACK1 overexpression is linked to acquired imatinib resistance in gastrointestinal stromal tumor. 2016 Mar 22 1
37 26919095 Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. 2016 Apr 5 3
38 24706111 microRNA-218 increase the sensitivity of gastrointestinal stromal tumor to imatinib through PI3K/AKT pathway. 2015 May 3
39 25182956 KIT and BRAF heterogeneous mutations in gastrointestinal stromal tumors after secondary imatinib resistance. 2015 Oct 2
40 25757539 PI3K/AKT/mTOR pathway is activated after imatinib secondary resistance in gastrointestinal stromal tumors (GISTs). 2015 Apr 8
41 25889792 The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells. 2015 Mar 24 2
42 25979368 Curcumin potentiates the anti-leukemia effects of imatinib by downregulation of the AKT/mTOR pathway and BCR/ABL gene expression in Ph+ acute lymphoblastic leukemia. 2015 Aug 3
43 26248946 Silencing of miR-21 sensitizes CML CD34+ stem/progenitor cells to imatinib-induced apoptosis by blocking PI3K/AKT pathway. 2015 Oct 3
44 26473951 Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release. 2015 1
45 24100660 Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with nilotinib against BCR-ABL-positive leukemia cells involves the ABL kinase domain mutation. 2014 Feb 1
46 24699303 Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia. 2014 Nov 1
47 25151958 AKT-induced reactive oxygen species generate imatinib-resistant clones emerging from chronic myeloid leukemia progenitor cells. 2014 Dec 1
48 23383209 Imatinib reverses doxorubicin resistance by affecting activation of STAT3-dependent NF-κB and HSP27/p38/AKT pathways and by inhibiting ABCB1. 2013 2
49 23462796 Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl. 2013 Jun 2
50 23749045 Autocrine insulin-like growth factor 1 and stem cell factor but not interleukin 6 support self-renewal of human myeloma cells. 2013 Jun 7 1