trichostatin A

AKT serine/threonine kinase 1 ; Homo sapiens







29 Article(s)
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1 35598597 Tanshinone IIA inhibits tissue factor expression induced by thrombin in human umbilical vein endothelial cells via PAR-1 and p38 MAPK signaling pathway. 2022 May 20 2
2 33513620 Low Dose of Trichostatin A Improves Radiation Resistance by Activating Akt/Nrf2-Dependent Antioxidation Pathway in Cancer Cells. 2021 Apr 1 2
3 32593284 Histone Deacetylase Inhibitor Trichostatin A Suppresses Cell Proliferation and Induces Apoptosis by Regulating the PI3K/AKT Signalling Pathway in Gastric Cancer Cells. 2020 3
4 29248540 Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition. 2018 Mar 2
5 28393191 Inactivation of EGFR/AKT signaling enhances TSA-induced ovarian cancer cell differentiation. 2017 May 1
6 28713892 Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. 2017 Sep 2
7 26509796 Trichostatin A, an Inhibitor of Histone Deacetylase, Inhibits the Viability and Invasiveness of Hypoxic Rheumatoid Arthritis Fibroblast-Like Synoviocytes via PI3K/Akt Signaling. 2016 Apr 4
8 27121018 Trichostatin A potentiates genistein-induced apoptosis and reverses EMT in HEp2 cells. 2016 Jun 1
9 25634603 Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and promotes apoptosis of esophageal squamous cell lines. 2015 Jun 2
10 26287365 Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. 2015 3
11 26436206 Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway. 2015 Nov 13 2
12 24456602 Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells. 2014 Apr 1
13 24562770 mTORC1/C2 and pan-HDAC inhibitors synergistically impair breast cancer growth by convergent AKT and polysome inhibiting mechanisms. 2014 Apr 3
14 23201405 Synergistic induction of miR-126 by hypoxia and HDAC inhibitors in cardiac myocytes. 2013 Jan 11 1
15 24157878 The epigenetic modifier trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition of lens epithelial cells. 2013 Oct 24 2
16 21380726 Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines. 2011 Jul 4
17 21826665 Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. 2011 Nov 1
18 21944112 Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells. 2011 Nov 1
19 20419833 Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells. 2010 Apr 28 2
20 19426671 Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway. 2009 Apr 15 2
21 19574087 PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells. 2009 Oct 2
22 19700647 Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition. 2009 Nov 1
23 18489729 Cellular conditioning with trichostatin A enhances the anti-stress response through up-regulation of HDAC4 and down-regulation of the IGF/Akt pathway. 2008 Aug 2
24 18495085 Trichostatin A improves insulin stimulated glucose utilization and insulin signaling transduction through the repression of HDAC2. 2008 Jul 1 1
25 18941460 Inhibitory effect of HGF on invasiveness of aggressive MDA-MB231 breast carcinoma cells, and role of HDACs. 2008 Nov 18 1
26 17209135 Activation of elastin transcription by transforming growth factor-beta in human lung fibroblasts. 2007 Apr 1
27 16773209 Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells. 2006 Jul 3
28 17018141 Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. 2006 Oct 3 1
29 16186112 Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes. 2005 Nov 18 4