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33446524 | In Vitro Evidence of Potential Interactions between CYP2C8 and Candesartan Acyl-β-D-glucuronide in the Liver. | 2021 Apr |
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33753217 | An automated cocktail method for in vitro assessment of direct and time-dependent inhibition of nine major cytochrome P450 enzymes - application to establishing CYP2C8 inhibitor selectivity. | 2021 Jul 1 |
1 |
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30630815 | Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans. | 2019 Apr |
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30709838 | Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8. | 2019 Apr |
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29712725 | Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling. | 2018 Jul |
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28653847 | Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8). | 2017 Nov 9 |
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26721703 | Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. | 2016 Jan |
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24591743 | 2D QSAR Study for Gemfibrozil Glucuronide as the Mechanism-based Inhibitor of CYP2C8. | 2013 Nov |
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22930276 | Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors. | 2012 Dec |
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21911547 | Studies to further investigate the inhibition of human liver microsomal CYP2C8 by the acyl-β-glucuronide of gemfibrozil. | 2011 Dec |
4 |
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16299161 | Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. | 2006 Jan |
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17178259 | Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. | 2006 Dec |
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15608133 | Cytochrome P450-mediated oxidation of glucuronide derivatives: example of estradiol-17beta-glucuronide oxidation to 2-hydroxy-estradiol-17beta-glucuronide by CYP 2C8. | 2005 Mar |
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15194707 | Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. | 2004 Oct |
2 |