Bile Acids and Salts

ATP binding cassette subfamily B member 4 ; Homo sapiens







41 Article(s)
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Pub. Year
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1 34022183 Monomeric bile acids modulate the ATPase activity of detergent-solubilized ABCB4/MDR3. 2021 3
2 34098996 Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy. 2021 Jun 7 1
3 32917728 Stimulation of ABCB4/MDR3 ATPase activity requires an intact phosphatidylcholine lipid. 2020 Dec 3
4 33132268 [Mechanism of Taurohyodeoxycholate-induced Biliary Phospholipid Efflux -Understanding the Function of the ABCB4 Enhancer for Developing Therapeutic Agents against Bile Salt-induced Liver Injury]. 2020 2
5 33383947 Gene Therapy for Progressive Familial Intrahepatic Cholestasis: Current Progress and Future Prospects. 2020 Dec 29 1
6 30730833 ABCB4/MDR3 in health and disease - at the crossroads of biochemistry and medicine. 2019 Sep 25 1
7 30930437 Molecular Mechanisms for Protection of Hepatocytes against Bile Salt Cytotoxicity. 2019 1
8 30964181 Elevated hepatic MDR3/ABCB4 is directly mediated by MiR-378a-5p in human obstructive cholestasis. 2019 Mar 1
9 31175181 Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters. 2019 Aug 1
10 31176036 Enhancing effect of taurohyodeoxycholate on ABCB4-mediated phospholipid efflux. 2019 Oct 1
11 31886153 Expression Analysis of ATP-Binding Cassette Transporters ABCB11 and ABCB4 in Primary Sclerosing Cholangitis and Variety of Pediatric and Adult Cholestatic and Noncholestatic Liver Diseases. 2019 1
12 29420298 The importance of membrane microdomains for bile salt-dependent biliary lipid secretion. 2018 Mar 1 2
13 27916445 Outcomes following partial external biliary diversion in patients with progressive familial intrahepatic cholestasis. 2017 Feb 1
14 28220208 ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population. 2017 Jul 1
15 25342496 Autoimmune BSEP disease: disease recurrence after liver transplantation for progressive familial intrahepatic cholestasis. 2015 Jun 1
16 26517915 Lipid flopping in the liver. 2015 Oct 1
17 24806754 Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4. 2014 May 1
18 25133187 Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts. 2014 1
19 23175273 Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells. 2013 Apr 1
20 23261441 Functional characterization of genetic variations in the MDR3 promoter. 2013 Jan 25 2
21 23468132 Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes. 2013 May 2
22 23593265 Detergent screening and purification of the human liver ABC transporters BSEP (ABCB11) and MDR3 (ABCB4) expressed in the yeast Pichia pastoris. 2013 5
23 24381502 Functional Characterization of ABCB4 Mutations Found in Low Phospholipid-Associated Cholelithiasis (LPAC). 2013 Dec 2
24 22343912 Chinese children with chronic intrahepatic cholestasis and high γ-glutamyl transpeptidase: clinical features and association with ABCB4 mutations. 2012 Aug 2
25 22859919 Hepatobiliary transport in health and disease. 2012 Apr 2
26 21056966 Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4. 2011 Feb 4
27 20040336 Therapeutic effect of bezafibrate against biliary damage: a study of phospholipid secretion via the PPARalpha-MDR3 pathway. 2010 Jan 1
28 19584064 ABCB4 gene mutations and single-nucleotide polymorphisms in women with intrahepatic cholestasis of pregnancy. 2009 Oct 1
29 18176959 Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump. 2008 Jan 7 1
30 18781607 A mutation in the canalicular phospholipid transporter gene, ABCB4, is associated with cholestasis, ductopenia, and cirrhosis in adults. 2008 Oct 1
31 18998069 Lessons from the toxic bile concept for the pathogenesis and treatment of cholestatic liver diseases. 2008 4
32 17523162 Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4. 2007 Jul 1
33 17608770 Mechanism of multidrug recognition by MDR1/ABCB1. 2007 Sep 1
34 16763017 Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11). 2006 Sep 3
35 15841457 Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis. 2005 May 1
36 14999697 BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis. 2004 Mar 3
37 12388190 Substitution of Trp1242 of TM17 alters substrate specificity of human multidrug resistance protein 3. 2003 Feb 2
38 11590139 Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter. 2001 Dec 14 8
39 11076400 Intracellular trafficking and regulation of canalicular ATP-binding cassette transporters. 2000 1
40 9155155 [The role of P-glycoprotein in the liver]. 1997 May 1
41 9566041 Participation of the multispecific organic anion transporter in hepatobiliary excretion of glutathione S-conjugates, drugs and other xenobiotics. 1997 Nov-Dec 1