2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid

BH3 interacting domain death agonist ; Homo sapiens







12 Article(s)
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1 29313279 A phase 1 study of PARP-inhibitor ABT-767 in advanced solid tumors with BRCA1/2 mutations and high-grade serous ovarian, fallopian tube, or primary peritoneal cancer. 2018 Oct 2
2 26508094 A randomized phase I/II study of ABT-888 in combination with temozolomide in recurrent temozolomide resistant glioblastoma: an NRG oncology RTOG group study. 2016 Jan 1
3 23032073 A randomized, double-blind, placebo-controlled phase 2 study of α4β2 agonist ABT-894 in adults with ADHD. 2013 Feb 2
4 21748252 Efficacy and safety of the novel α₄β₂ neuronal nicotinic receptor partial agonist ABT-089 in adults with attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled crossover study. 2012 Feb 2
5 22393246 ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines. 2012 Jun 1
6 22464442 Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells. 2012 Mar 30 1
7 22764103 Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737. 2012 Jul 5 2
8 23190604 ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells. 2012 Nov 29 5
9 21933888 Synergistic activity of fenretinide and the Bcl-2 family protein inhibitor ABT-737 against human neuroblastoma. 2011 Nov 15 1
10 19632048 A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain. 2009 Dec 3
11 17943175 Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway. 2008 Jan 1
12 16143263 Potent farnesyltransferase inhibitor ABT-100 abrogates acute allograft rejection. 2005 Sep 3